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Sphingosine 1-phosphate receptor 2 promotes erythrocyte clearance by vascular smooth muscle cells in intraplaque hemorrhage through MFG-E8 production

期刊: CELLULAR SIGNALLING, 2022; 98 ()

Intraplaque hemorrhage (IPH) accelerates atherosclerosis progression. To scavenge excessive red blood cells (RBCs), vascular smooth muscle cells (VSMC......

JIF:4.132

CHD4 mediates SOX2 transcription through TRPS1 in luminal breast cancer

期刊: CELLULAR SIGNALLING, 2022; 100 ()

Chromodomain helicase DNA binding protein 4 (CHD4), as a core component of the nucleosome remodeling and deactetylase (NuRD) complex, participated in ......

JIF:4.132

Silencing of RNA binding protein, ZFP36L1, promotes epithelial-mesenchymal transition in liver cancer cells by regulating transcription factor ZEB2

期刊: CELLULAR SIGNALLING, 2022; 100 ()

RNA binding proteins (RBPs) of the zinc finger protein 36 family including zinc finger protein 36 like 1 (ZFP36L1) are implicated in cancer, however, ......

JIF:4.132

Nuak kinase signaling in development and disease of the central nervous system

期刊: CELLULAR SIGNALLING, 2022; 100 ()

Protein kinases represent important signaling hubs for a variety of biological functions. Many kinases are traditionally studied for their roles in ca......

JIF:4.132

Ror2 mediates chronic post-thoracotomy pain by inducing the transformation of A1/A2 reactive astrocytes in rats

期刊: CELLULAR SIGNALLING, 2022; 89 ()

Ror2 plays an important role in neuronal development, neuronal plasticity, and neuropathic pain. In our previous pilot study, we found that Ror2 and G......

JIF:4.132

Glioma cell-derived FGF20 suppresses macrophage function by activating beta-catenin

期刊: CELLULAR SIGNALLING, 2022; 89 ()

Macrophages, which are the main regulators of the tumor-associated microenvironment, play a crucial role in the progression of various tumors. The ant......

JIF:4.132

CRISPR/Cas9-mediated knockout of SGLT1 inhibits proliferation and alters metabolism of gastric cancer cells

期刊: CELLULAR SIGNALLING, 2022; 90 ()

Background: The roles played by sodium/glucose cotransporters 1 (SGLT1) that transport glucose in cells independent of extracellular glucose concentra......

JIF:4.132

HOXD9 transcriptionally induced UXT facilitate breast cancer progression via epigenetic modification of RND3

期刊: CELLULAR SIGNALLING, 2022; 90 ()

Background: Ubiquitously expressed transcript (UXT) is a prefoldin-like protein. It was reported that UXT played vital role in several cancer types. H......

JIF:4.132

MiR-155 regulates m(6)A level and cell progression by targeting FTO in clear cell renal cell carcinoma

期刊: CELLULAR SIGNALLING, 2022; 91 ()

Although FTO, as an eraser of N6-methyladenosine (m(6)A), plays context-dependent tumor-suppressive and oncogenic roles in various cancer type, underl......

JIF:4.132

B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells

期刊: CELLULAR SIGNALLING, 2022; 94 ()

B-cell receptor (BCR) signaling plays a major role in the pathogenesis of B-cell malignancies and is an established target for therapy, including in c......

JIF:4.132

EP300 promotes renal tubular epithelial cell fibrosis by increasing HIF2? expression in diabetic nephropathy

期刊: CELLULAR SIGNALLING, 2022; 98 ()

Renal tubular damage occurs early in diabetic nephropathy (DN) and may play a key role in the progression of kidney disease. E1A binding protein P300 ......

JIF:4.132

Activating transcription factor 6 protects against endothelial barrier dysfunction

期刊: CELLULAR SIGNALLING, 2022; 99 ()

Background: Endothelial hyperpermeability is associated with sepsis and acute respiratory distress syndrome (ARDS). The identification of molecular pa......

JIF:4.132

Beta-arrestins in the context of cardiovascular diseases: Focusing on angiotensin II type 1 receptor (AT1R)

期刊: CELLULAR SIGNALLING, 2022; 92 ()

Cardiovascular diseases are the leading cause of death worldwide. The renin-angiotensin-aldosterone system is one of the major regulators of cardiovas......

JIF:4.132

Fast detection of PKA activity in Saccharomyces cerevisiae cell population using AKAR fluorescence resonance energy transfer probes

期刊: CELLULAR SIGNALLING, 2022; 92 ()

In Saccharomyces cerevisiae, the protein kinase A (PKA) plays a central role in the control of metabolism, stress resistance and cell cycle progressio......

JIF:4.132

GLI3 and androgen receptor are mutually dependent for their malignancy-promoting activity in ovarian and breast cancer cells

期刊: CELLULAR SIGNALLING, 2022; 92 ()

Hedgehog signaling pathway has been previously elucidated to be inappropriately activated in many human cancers, including ovarian and breast cancer. ......

JIF:4.132

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