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Multi-omics analysis reveals prognostic value of tumor mutation burden in hepatocellular carcinoma

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

BackgroundHepatocellular carcinoma (HCC) was the sixth common malignancies characteristic with highly aggressive in the world. It was well established......

SHP2 inhibition enhances the anticancer effect of Osimertinib in EGFR T790M mutant lung adenocarcinoma by blocking CXCL8 loop mediated stemness

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

BackgroundAdditional epidermal growth factor receptor (EGFR) mutations confer the drug resistance to generations of EGFR targeted tyrosine kinase inhi......

LINC00115 promotes stemness and inhibits apoptosis of ovarian cancer stem cells by upregulating SOX9 and inhibiting the Wnt/beta-catenin pathway through competitively binding to microRNA-30a

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

Objective Long non-coding RNAs (lncRNAs) and microRNAs (miRs) are differentially expressed in ovarian cancer (OC) cells and influence OC progression. ......

Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

Malignant tumor has become one of the major diseases that seriously endangers human health. Numerous studies have demonstrated that tumor microenviron......

CircFAM13B promotes the proliferation of hepatocellular carcinoma by sponging miR-212, upregulating E2F5 expression and activating the P53 pathway

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

Background Most of the biological functions of circular RNAs (circRNAs) and the potential underlying mechanisms in hepatocellular carcinoma (HCC) have......

Elevated exosome-derived miRNAs predict osimertinib resistance in non-small cell lung cancer

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

Background: Non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations will inevitably develop drug resistance......

FZD2 promotes TGF-beta-induced epithelial-to-mesenchymal transition in breast cancer via activating notch signaling pathway

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

Background Breast cancer (BC) is one of the commonest female cancers, which is characterized with high incidence. Although treatments have been improv......

The effect of miR-539 regulating TRIAP1 on the apoptosis, proliferation, migration and invasion of osteosarcoma cells

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

Objective The purpose of this study is to explore the effect of miRNA-539 on osteosarcoma (OS) and the underlying mechanism, so as to find a new metho......

Using dynamic cell communication improves treatment strategies of breast cancer

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

Several insights from the clinical treatment of breast cancer patients have revealed that only a portion of patients achieve the expected curative eff......

YWHAE as an HE4 interacting protein can influence the malignant behaviour of ovarian cancer by regulating the PI3K/AKT and MAPK pathways

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

Background Malignant tumours of the female reproductive system threaten the lives and health of women worldwide, with ovarian cancer having the highes......

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms re......

NCK1-AS1 promotes the progression of melanoma by accelerating cell proliferation and migration via targeting miR-526b-5p/ADAM15 axis

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

BackgroundLong non-coding RNAs (lncRNAs) are vital regulators of gene expression and cellular processes in multiple cancers, including melanoma. Never......

Genistein as a regulator of signaling pathways and microRNAs in different types of cancers

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

Cancers are complex diseases orchestrated by a plethora of extrinsic and intrinsic factors. Research spanning over several decades has provided better......

HOXB7 acts as an oncogenic biomarker in head and neck squamous cell carcinoma

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

Background The homeobox gene Homeobox B7 (HOXB7) is overexpressed across a range of cancers and promotes tumorigenesis through varying effects on prol......

IGHG1 upregulation promoted gastric cancer malignancy via AKT/GSK-3 beta/beta-Catenin pathway

期刊: CANCER CELL INTERNATIONAL, 2021; 21 (1)

Background: Despite current advances in gastric cancer treatment, disease metastasis and chemo-resistance remain as major hurdles against better overa......

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