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Lactobacillus rhamnosus attenuates intestinal inflammation induced by Fusobacterium nucleatum infection by restoring the autophagic flux

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 47 (1)

Autophagy plays a dual role in the responses to the gut microflora. The present study aimed to examine the effects of Lactobacillus rhamnosus (L. rham......

Regulatory role of DEPTOR-mediated cellular autophagy and mitochondrial reactive oxygen species in angiogenesis in multiple myeloma

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 47 (2)

DEPTOR, an inhibitor of mammalian target of rapamycin (mTOR), is essential for the survival of multiple myeloma (MM) cells. The expression level of DE......

Atrial fibrosis underlying atrial fibrillation (Review)

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 47 (3)

Atrial fibrillation (AF) is one of the most common tachyarrhythmias observed in the clinic and is characterized by structural and electrical remodelli......

Quercetin reverses TNF-alpha induced osteogenic damage to human periodontal ligament stem cells by suppressing the NF-kappa B/NLRP3 inflammasome pathway

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 47 (4)

Quercetin (Quer) is a typical antioxidant flavonoid from plants that is involved in bone metabolism, as well as in the progression of inflammatory dis......

Helichrysetin and TNF-alpha synergistically promote apoptosis by inhibiting overactivation of the NF-kappa B and EGFR signaling pathways in HeLa and T98G cells

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 47 (4)

Tumor necrosis factor-alpha (TNF-alpha) has different effects on apoptosis depending on activation or inactivation of the nuclear factor-kappa B (NF-k......

Lipoxin A4 protects against paraquat-induced acute lung injury by inhibiting the TLR4/MyD88-mediated activation of the NF-kappa B and PI3K/AKT pathways

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 47 (5)

Paraquat (PQ) causes serious oxidative stress and inflammatory responses, particularly to the lungs. Since lipoxin A4 (LXA4) functions as an anti-infl......

Sinigrin attenuates angiotensin II-induced kidney injury by inactivating nuclear factor-kappa B and extracellular signal-regulated kinase signaling in vivo and in vitro

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 48 (2)

The present study investigated the function of sinigrin in angiotensin II (Ang II)-induced renal damage. The results demonstrated that systolic blood ......

Effect and mechanism of propranolol on promoting osteogenic differentiation and early implant osseointegration

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 48 (4)

The present study aimed to investigate the effect of beta-receptor blocker propranolol on early osseointegration of pure titanium implants and the und......

Omega-3 polyunsaturated fatty acids inhibit IL-11/STAT3 signaling in hepatocytes during acetaminophen hepatotoxicity

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 48 (4)

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) exert a negative effect on IL-6 production in several liver disorders, including cirrhosis, acute live......

Oxymatrine attenuates oxidized low-density lipoprotein-induced HUVEC injury by inhibiting NLRP3 inflammasome-mediated pyroptosis via the activation of the SIRT1/Nrf2 signaling pathway

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 48 (4)

Oxymatrine, a quinolizidine alkaloid isolated from the traditional Chinese herb Sophora flavescens Aiton, has been demonstrated to exert anti-inflamma......

miR-142-3p targets AC9 to regulate sciatic nerve injury-induced neuropathic pain by regulating the cAMP/AMPK signalling pathway

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 47 (2)

The aim of the present study was to investigate the effects of microRNA (miR)-142-3p on neuropathic pain caused by sciatic nerve injury in chronic com......

COVID-19 and ischemic stroke: Mechanisms of hypercoagulability

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 47 (3)

During the coronavirus disease 2019 (COVID-19) pandemic, some patients with severe COVID-19 exhibited complications such as acute ischemic stroke (AIS......

Peptide Szeto-Schiller 31 ameliorates doxorubicin-induced cardiotoxicity by inhibiting the activation of the p38 MAPK signaling pathway

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 47 (4)

Oxidative stress serves a key role in doxorubicin (DOX)-induced cardiotoxicity. The peptide Szeto-Schiller (SS)31 is an efficacious antioxidant with t......

Hydrogen sulfide inhibits endoplasmic reticulum stress through the GRP78/mTOR pathway in rat chondrocytes subjected to oxidative stress

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 47 (4)

The activation of oxidative stress is a primary cause of chondrocyte apoptosis in osteoarthritis (OA). The 78-kDa glucose-regulated protein (GRP78)/ma......

Downregulation of lncRNA MIR181A2HG by high glucose impairs vascular endothelial cell proliferation and migration through the dysregulation of the miRNAs/AKT2 axis

期刊: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2021; 47 (4)

Endothelial dysfunction and diabetic vascular disease induced by chronic hyperglycemia involve complex interactions among high glucose, long non-codin......

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