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Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF-κB/TLR4 signals

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; 33 (8)

Cadmium (Cd) is one of the most hazardous metals to the environment and human health. Neurotoxicity is of the most serious hazards caused by Cd. Mirta......

Gas chromatography-tandem mass spectrometric analysis of metaldehyde and its metabolite acetaldehyde in initial assessment of hemodialysis abatement of toxicity in live animals

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; 33 (9)

Metaldehyde consumption by pets and other mammals constitute medical emergencies ideally requiring rapid poison removal. The purpose of this study was......

Identification of plastic rice in adulterated raw and cooked rice

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; ()

In the present study, attempts have been made to identify the presence of plastic rice in adulterated raw and cooked rice by comparing the composition......

C-Glucosyl Xanthone derivative Mangiferin downregulates the JNK3 mediated caspase activation in Almal induced neurotoxicity in differentiated SHSY-5Y neuroblastoma cells

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; 33 (9)

IntroductionC-Glucosyl Xanthone derivatives were assessed to inhibit the JNK3 mediated Caspase pathway in Almal (Aluminum Maltolate) induced neurotoxi......

Comparison of the effect of vitamin C and selenium nanoparticles on gentamicin-induced renal impairment in male rats: a biochemical, molecular and histological study

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; 33 (4)

Renal failure caused by gentamicin is mainly mediated through oxidative damage, inflammation, and apoptosis. Hence, vitamin C and selenium, which have......

Investigating the potential anti-inflammatory mechanism of benzophenone compounds from the leaves of Aquilaria sinensis (Lour.) Gilg based on network pharmacology and molecular docking strategies

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; 33 (8)

BackgroundAquilaria sinensis (Lour.) Gilg (ASG) has been used as traditional medicine for centuries. However, the active ingredients from leaves and t......

Aurintricarboxylic acid mitigates cigarette smoke extract induced oxidative stress and pulmonary inflammation via inhibition of NF-κB/p65 signaling

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; 33 (1)

Cigarette smoke (CS) induced emphysema and chronic pulmonary inflammation are major comorbidities of chronic obstructive pulmonary disease (COPD), a m......

Long noncoding RNAs: biogenesis, regulation, function, and their emerging significance in toxicology

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; ()

The repertoire of regulatory noncoding RNAs (ncRNAs) has been enriched by the inclusion of long noncoding RNA (lncRNA) that are longer than 200 nt. So......

Inhibition of glutathione generation in hepatic steatotic rats augments oxidative stress

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; ()

Fatty liver disease has been strongly associated with a low glutathione (GSH) level in hepatocytes with increased oxidative stress, which is criticall......

A critical assessment of the whole plant-based phytotherapeutics from Withania somnifera (L.) Dunal with respect to safety and efficacy vis-a-vis leaf or root extract-based formulation

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; 33 (8)

Withania somnifera (L.) Dunal, popularly known as Ashwagandha or Indian ginseng, is well acclaimed for its health-enhancing effects, including its pot......

Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; 33 (2)

There is increasing evidence that the GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) plays important roles in the formation of various......

Development of reliable quantitative structure-toxicity relationship models for toxicity prediction of benzene derivatives using semiempirical descriptors

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; 33 (3)

The Health and environmental hazards of benzene and nitrobenzene (NB) derivatives have remained a topic of interest of researchers. In silico methods ......

Interaction of quercetin and 5-fluorouracil: cellular and pharmacokinetic study

期刊: TOXICOLOGY MECHANISMS AND METHODS, 2023; 33 (6)

5-fluorouracil (5-FU) is a widely used chemotherapeutic agent, and its uncontrolled blood levels contribute to toxicity. Quercetin, as an important fl......

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