期刊： INVESTIGATIONAL NEW DRUGS, 2021; 39 (5)
Recently, we read a paper "Preclinical assessment of histone deacetylase inhibitor quisinostat as a therapeutic agent against esophageal squamous cell......
期刊： INVESTIGATIONAL NEW DRUGS, 2021; 39 (5)
Background: Pegylated recombinant human arginase (PEG-BCT-100) is an arginine depleting drug. Preclinical studies showed that HCC is reliant on exogen......
期刊： INVESTIGATIONAL NEW DRUGS, 2021; 39 (5)
Diffuse midline gliomas (DMGs), which are malignant, fast-growing and entail a poor prognosis, are a rare subtype of glial tumor. DMGs harboring H3 K2......
期刊： INVESTIGATIONAL NEW DRUGS, 2021; 39 (5)
Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have led to great advances in the treatment of non-small cell lung cancer (NSC......
期刊： INVESTIGATIONAL NEW DRUGS, 2021; 39 (5)
The families of miR-34 and miR-449 share the same seed region. However, the members showed differential effects on the expression of B7-H3 and PD-L1 i......
期刊： INVESTIGATIONAL NEW DRUGS, 2021; 39 (5)
Gastric cancer (GC) has the third highest rate of cancer incidence and mortality worldwide. First-line immune checkpoint inhibitor (ICI) therapy for a......
期刊： INVESTIGATIONAL NEW DRUGS, 2021; 39 (5)
Compound epidermal growth factor receptor (EGFR) mutations are defined as double or multiple independent mutations of the EGFR tyrosine kinase domain ......
期刊： INVESTIGATIONAL NEW DRUGS, 2021; 39 (5)
Hepatocellular carcinoma (HCC) is a malignancy with a poor prognosis. E3 ubiquitin-protein ligases play essential roles in HCC, such as regulating pro......
期刊： INVESTIGATIONAL NEW DRUGS, 2021; 39 (5)
China has been criticized for the long drug delay for a long time. There was little understanding of Chinese drug lag formation from the investigation......
期刊： INVESTIGATIONAL NEW DRUGS, 2021; 39 (5)
In order to fuel the uncontrolled cell proliferation and division, tumor cells reprogram the energy metabolism to Warburg effect, where glucose is pre......
期刊： INVESTIGATIONAL NEW DRUGS, ; ()
As a potential cancer therapy, we developed a recombinant adenovirus named Ad-VT, which was designed to express the apoptosis-inducing gene (apoptin) ......
期刊： INVESTIGATIONAL NEW DRUGS, ; ()
Our previous studies revealed that MYCN downregulates the expression of DKK3, activates the Wnt/beta-catenin signalling pathway at the transcriptional......
期刊： INVESTIGATIONAL NEW DRUGS, ; ()
Due to immune impairment and lymphocyte enrichment of oral squamous cell carcinoma (OSCC), anti-PD-1/PD-L1 therapy is regarded as a potential treatmen......
期刊： INVESTIGATIONAL NEW DRUGS, ; ()
Background Nowadays, lung cancer seriously affects human health in the world. Therefore, it is of great significance to develop effective anti-lung ca......
期刊： INVESTIGATIONAL NEW DRUGS, ; ()
Neuroblastoma (NB) is a common tumor in children, usually in the retroperitoneum. After various treatments, low- and intermediate-risk patients have a......
