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Case Study of the Response of N-6-Methyladenine DNA Modification to Environmental Stressors in the Unicellular Eukaryote Tetrahymena thermophila

期刊: MSPHERE, 2021; 6 (3)

Rediscovered as a potential epigenetic mark, N-6-methyladenine DNA modification (6mA) was recently reported to be sensitive to environmental stressors......

Extensive Genetic Diversity and Widespread Azole Resistance in Greenhouse Populations of Aspergillus fumigatus in Yunnan, China

期刊: MSPHERE, 2021; 6 (1)

Aspergillus fumigatus is the main cause of invasive aspergillosis (IA) with a high annual global incidence and mortality rate. Recent studies have ind......

A PorX/PorY and o-(P) Feedforward Regulatory Loop Controls Gene Expression Essential for Porphyromonas gingivalis Virulence

期刊: MSPHERE, 2021; 6 (3)

The PorX/PorY two-component system in the periodontal pathogen Porphyromonas gingivalis controls the expression of the por genes, encoding a type IX s......

Reversing Antibiotic Resistance Caused by Mobile Resistance Genes of High Fitness Cost

期刊: MSPHERE, 2021; 6 (3)

The reversibility of antibiotic resistance is theoretically attractive due to the prospect of restoring the clinical potency of antibiotics. It is imp......

The pH-Responsive Transcription Factors YlRim101 and Mhy1 Regulate Alkaline pH-Induced Filamentation in the Dimorphic Yeast Yarrowia lipolytica

期刊: MSPHERE, 2021; 6 (3)

Environmental pH influences cell growth and differentiation. In the dimorphic yeast Yarrowia lipolytica, neutral-alkaline pH strongly induces the yeas......

An Expanded Gene Catalog of Mouse Gut Metagenomes

期刊: MSPHERE, 2021; 6 (1)

High-quality and comprehensive reference gene catalogs are essential for metagenomic research. The rather low diversity of samples used to construct e......

A Novel Phage Infecting Alteromonas Represents a Distinct Group of Siphophages Infecting Diverse Aquatic Copiotrophs

期刊: MSPHERE, 2021; 6 (3)

Bacteriophages play critical roles in impacting microbial community succession both ecologically and evolutionarily. Although the majority of phage ge......

Covariation of the Fecal Microbiome with Diet in Nonpasserine Birds

期刊: MSPHERE, 2021; 6 (3)

Opportunistic feeding and multiple other environment factors can modulate the gut microbiome, and bias conclusions, when wild animals are used for stu......

Streptococcus suis MsmK: Novel Cell Division Protein Interacting with FtsZ and Maintaining Cell Shape

期刊: MSPHERE, 2021; 6 (2)

Bacteria of different shapes have adopted distinct mechanisms to faithfully coordinate morphogenesis and segregate their chromosomes prior to cell div......

Bioinformatic and Functional Characterization of Hsp70s in Myxococcus xanthus

期刊: MSPHERE, 2021; 6 (3)

Hsp70 proteins are among the most ubiquitous chaperones and play important roles in maintaining proteostasis and resisting environmental stress. Multi......

Emergence of Hypervirulent Carbapenem-Resistant Klebsiella pneumoniae Coharboring a bla(NDM-1)-Carrying Virulent Plasmid and a bla(KPC-2)-Carrying Plasmid in an Egyptian Hospital

期刊: MSPHERE, 2021; 6 (3)

The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates in Egyptian hospitals has been reported. However, the genetic basis and an......

Pathogenesis Study of Enterovirus 71 Using a Novel Human SCARB2 Knock-In Mouse Model

期刊: MSPHERE, 2021; 6 (2)

Enterovirus 71 (EV71) can cause a severe hand-foot-mouth disease in children. However, the precise mechanism of EV71-associated disease, particularly ......

The Histone Deacetylases MoRpd3 and MoHst4 Regulate Growth, Conidiation, and Pathogenicity in the Rice Blast Fungus Magnaporthe oryzae

期刊: MSPHERE, 2021; 6 (3)

As the causal agent of the blast disease, Magnaporthe oryzae is one of the most destructive fungal pathogens of rice. Histone acetylation/deacetylatio......

The Cytospora chrysosperma Virulence Effector CcCAP1 Mainly Localizes to the Plant Nucleus To Suppress Plant Immune Responses

期刊: MSPHERE, 2021; 6 (1)

Canker disease is caused by the fungus Cytospora chrysosperma and damages a wide range of woody plants, causing major losses to crops and native plant......

Development of a New Reverse Genetics System for Ebola Virus

期刊: MSPHERE, 2021; 6 (3)

Ebola virus (EBOV) is a highly pathogenic negative-stranded RNA virus that has caused several deadly endemics in the past decades. EBOV reverse geneti......

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