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Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (1)

Background Oncolytic viro-immunotherapy holds promise for cancer treatment. While immune activation can be robustly triggered by oncolytic viruses, ne......

Inactivation of 3-hydroxybutyrate dehydrogenase type 2 promotes proliferation and metastasis of nasopharyngeal carcinoma by iron retention

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (1)

Background 3-Hydroxybutyrate dehydrogenase type 2 (BDH2) is known to catalyse a rate-limiting step in the biogenesis of the mammalian siderophore and ......

Energy metabolism manipulates the fate and function of tumour myeloid-derived suppressor cells

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (1)

In recent years, a large number of studies have been carried out in the field of immune metabolism, highlighting the role of metabolic energy reprogra......

Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (2)

Background Ferroptosis is an iron-dependent, lipid peroxide-mediated cell death that may be exploited to selective elimination of damaged and malignan......

MFN1-dependent alteration of mitochondrial dynamics drives hepatocellular carcinoma metastasis by glucose metabolic reprogramming

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (2)

Background Mitochondrial dynamics plays an important role in tumour progression. However, how these dynamics integrate tumour metabolism in hepatocell......

MiR-107 confers chemoresistance to colorectal cancer by targeting calcium-binding protein 39

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (5)

Background Chemoresistance remains a critical event that accounts for colorectal cancer (CRC) lethality. The aim of this study is to explore the abili......

Preoperative detection of KRAS G12D mutation in ctDNA is a powerful predictor for early recurrence of resectable PDAC patients

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (6)

Background About 25-37% of resectable pancreatic ductal adenocarcinoma (PDAC) had a great chance of early recurrence after radical resection, which is......

PLAGL2 promotes epithelial-mesenchymal transition and mediates colorectal cancer metastasis via beta-catenin-dependent regulation of ZEB1

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (4)

Background We previously demonstrated that the pleomorphic adenoma gene like-2 (PLAGL2) is involved in the pathogenesis of Hirschsprung disease. Enhan......

Therapeutically targeting head and neck squamous cell carcinoma through synergistic inhibition of LSD1 and JMJD3 by TCP and GSK-J1

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (4)

Background The histone demethylase LSD1 is a key mediator driving tumorigenesis, which holds potential as a promising therapeutic target. However, tre......

Association of the tumour stroma percentage in the preoperative biopsies with lymph node metastasis in colorectal cancer

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (3)

BACKGROUND: Preoperative prediction of lymph node (LN) status is integral to determining the most appropriate treatment strategy for colorectal cancer......

Combined lifestyle factors, incident cancer, and cancer mortality: a systematic review and meta-analysis of prospective cohort studies

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (7)

Background Cancer poses a huge disease burden, which could be reduced by adopting healthy lifestyles mainly composed of healthy diet, body weight, phy......

DKC1 enhances angiogenesis by promoting HIF-1 alpha transcription and facilitates metastasis in colorectal cancer

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (5)

Background Dyskeratosis congenita 1 (DKC1) is dysregulated in several cancers. However, the expression and function of DKC1 in colorectal cancer (CRC)......

Targeting CD133 reverses drug-resistance via the AKT/NF-kappa B/MDR1 pathway in colorectal cancer

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (9)

Background Recent studies have shown that multidrug resistance may be induced by the high stemness of cancer cells. Following prolonged chemotherapy, ......

Identification and validation of an immunogenic subtype of gastric cancer with abundant intratumoural CD103(+)CD8(+) T cells conferring favourable prognosis

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (10)

Background Intratumoural CD103(+)CD8(+) T cells have been linked to prolonged survival in several malignancies. However, the clinical significance of ......

Regulation of the small GTPase Ran by miR-802 modulates proliferation and metastasis in colorectal cancer cells

期刊: BRITISH JOURNAL OF CANCER, 2020; 122 (11)

Background The small GTPase Ran is upregulated in multiple cancers and fundamental for cancer cell survival and progression, but its significance and ......

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