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Subicular Caspase-1 Contributes to Pharmacoresistance in Temporal Lobe Epilepsy

期刊: ANNALS OF NEUROLOGY, 2021; 90 (3)

Objective Unidentified mechanisms largely restrict the viability of effective therapies in pharmacoresistant epilepsy. Our previous study revealed tha......

MED27 Variants Cause Developmental Delay, Dystonia, and Cerebellar Hypoplasia

期刊: ANNALS OF NEUROLOGY, 2021; 89 (4)

The Mediator multiprotein complex functions as a regulator of RNA polymerase II-catalyzed gene transcription. In this study, exome sequencing detected......

Heritability Enrichment Implicates Microglia in Parkinson's Disease Pathogenesis

期刊: ANNALS OF NEUROLOGY, ; ()

Objective Understanding how different parts of the immune system contribute to pathogenesis in Parkinson's disease is a burning challenge with importa......

Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi-Omics

期刊: ANNALS OF NEUROLOGY, 2021; 89 (3)

Objective: Gut microbiome alterations in Parkinson disease (PD) have been reported repeatedly, but their functional relevance remains unclear. Fecal m......

Life Course Adiposity and Amyotrophic Lateral Sclerosis: A Mendelian Randomization Study

期刊: ANNALS OF NEUROLOGY, 2020; 87 (3)

Objective Observational studies have indicated that life course adiposity is associated with amyotrophic lateral sclerosis (ALS). However, whether suc......

ATPase Domain AFG3L2 Mutations Alter OPA1 Processing and Cause Optic Neuropathy

期刊: ANNALS OF NEUROLOGY, 2020; 88 (1)

Objective Dominant optic atrophy (DOA) is the most common inherited optic neuropathy, with a prevalence of 1:12,000 to 1:25,000. OPA1 mutations are fo......

Impairment of the Glymphatic Pathway and Putative Meningeal Lymphatic Vessels in the Aging Human

期刊: ANNALS OF NEUROLOGY, 2020; 87 (3)

Objective Aging is a major risk factor for numerous neurological disorders, and the mechanisms underlying brain aging remain elusive. Recent animal st......

Coffee Consumption and Risk of Stroke: A Mendelian Randomization Study

期刊: ANNALS OF NEUROLOGY, 2020; 87 (4)

Objective Observational epidemiological studies have reported a relationship between coffee intake and risk of stroke. However, evidence for this asso......

GGPS1Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome

期刊: ANNALS OF NEUROLOGY, 2020; 88 (2)

Objective A hitherto undescribed phenotype of early onset muscular dystrophy associated with sensorineural hearing loss and primary ovarian insufficie......

Ultra-Early Blood Pressure Reduction Attenuates Hematoma Growth and Improves Outcome in Intracerebral Hemorrhage

期刊: ANNALS OF NEUROLOGY, 2020; 88 (2)

Objective The aim was to investigate whether intensive blood pressure treatment is associated with less hematoma growth and better outcome in intracer......

Transcranial Magnetic Stimulation Promotes Gait Training in Parkinson Disease

期刊: ANNALS OF NEUROLOGY, 2020; 88 (5)

Objective To determine whether priming with 1 or 25Hz repetitive transcranial magnetic stimulation (rTMS) will enhance the benefits from treadmill tra......

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