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Hippocampal neurogenesis interferes with extinction and reinstatement of methamphetamine-associated reward memory in mice

期刊: NEUROPHARMACOLOGY, 2021; 196 ()

Drugs of abuse, including morphine and cocaine, can reduce hippocampal neurogenesis (HN). Whereas promotion of HN is being increasingly recognized as ......

Nicotine withdrawal induces hyperalgesia via downregulation of descending serotonergic pathway in the nucleus raphe magnus

期刊: NEUROPHARMACOLOGY, 2021; 189 ()

Patients deprived of cigarettes exhibit increased pain sensitivity during perioperative periods, yet the underlying neuroanatomical and molecular base......

Angiotensin II type 1 receptor blockade attenuates posttraumatic stress disorder-related chronic pain by inhibiting glial activation in the spinal cord

期刊: NEUROPHARMACOLOGY, 2021; 196 ()

Clinically, posttraumatic stress disorder (PTSD) and chronic pain are highly comorbid conditions, but the underlying mechanisms of and therapeutic str......

Sigma ligands as potent inhibitors of A beta and A beta Os in neurons and promising therapeutic agents of Alzheimer's disease

期刊: NEUROPHARMACOLOGY, 2021; 190 ()

Alzheimer's disease (AD) is an age-related neurodegenerative disease and characterized by dementia, memory decline, loss of learning and cognitive dis......

Activation of the spinal EGFR signaling pathway in a rat model of cancer-induced bone pain with morphine tolerance

期刊: NEUROPHARMACOLOGY, 2021; 196 ()

Cancer-induced bone pain (CIBP) is considered to be one of the most difficult pain conditions to treat. Morphine, an analgesic drug, is widely used in......

Early-life sevoflurane exposure impairs fear memory by suppressing extracellular signal-regulated kinase signaling in the bed nucleus of stria terminalis GABAergic neurons

期刊: NEUROPHARMACOLOGY, 2021; 191 ()

Sevoflurane exposure in neonates induces long-term impairment of learning and memory; however, its effect on cognition in the later developmental peri......

Oxytocin mediates neuroprotection against hypoxic-ischemic injury in hippocampal CA1 neuron of neonatal rats

期刊: NEUROPHARMACOLOGY, 2021; 187 ()

Neonatal hypoxic-ischemic encephalopathy (NHIE) is one of the most prevalent causes of death during the perinatal period. The lack of exposure to oxyt......

A prophylactic effect of macrophage-colony stimulating factor on chronic stress-induced depression-like behaviors in mice

期刊: NEUROPHARMACOLOGY, 2021; 193 ()

Innate immune activation has been shown to reduce the severity of nervous system disorders such as brain ischemia and traumatic brain damage. Macropha......

Presynaptic bouton compartmentalization and postsynaptic density-mediated glutamate receptor clustering via phase separation

期刊: NEUROPHARMACOLOGY, 2021; 193 ()

Neuronal synapses encompass three compartments: presynaptic axon terminal, synaptic cleft, and postsynaptic dendrite. Each compartment contains densel......

A multispecies probiotic accelerates fear extinction and inhibits relapse in mice: Role of microglia

期刊: NEUROPHARMACOLOGY, 2021; 193 ()

The relapse of fear memory remains a clinical challenge in treatment of fear-related disorders. Here we tested the effects and underlying mechanisms o......

Hippocampal miR-211-5p regulates neurogenesis and depression-like behaviors in the rat

期刊: NEUROPHARMACOLOGY, 2021; 194 ()

Emerging evidence has shown that microRNAs (miRNAs) contribute to the pathogenesis of depression, a potentially life-threatening and disabling mental ......

Intranasal vasopressin modulates resting state brain activity across multiple neural systems: Evidence from a brain imaging machine learning study

期刊: NEUROPHARMACOLOGY, 2021; 190 ()

Arginine vasopressin (AVP), a neuropeptide with widespread receptors in brain regions important for socioemotional processing, is critical in regulati......

Orexin-A differentially modulates inhibitory and excitatory synaptic transmission in rat inner retina

期刊: NEUROPHARMACOLOGY, 2021; 187 ()

In this work, modulation by orexin-A of the release of glutamate and GABA from bipolar and amacrine cells respectively was studied by examining the ef......

The role of oxidative stress in the susceptibility of noise-impaired cochleae to synaptic loss induced by intracochlear electrical stimulation

期刊: NEUROPHARMACOLOGY, 2021; 196 ()

Intracochlear electrical stimulation (ES) generated by cochlear implants (CIs) is used to activate auditory nerves to restore hearing perception in de......

Intranasal 15d-PGJ2 ameliorates brain glucose hypometabolism via PPAR gamma-dependent activation of PGC-1 alpha/GLUT4 signalling in APP/PS1 transgenic mice

期刊: NEUROPHARMACOLOGY, 2021; 196 ()

Targeting the common molecular mechanism of type 2 diabetes mellitus and Alzheimer's disease (AD), including dysregulation of glucose metabolism, insu......

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