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Gut-Lung Dysbiosis Accompanied by Diabetes Mellitus Leads to Pulmonary Fibrotic Change through the NF-KB Signaling Pathway

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (5)

Growing evidence shows that the lungs are an unavoidable target organ of diabetic complications. However, the pathologic mechanisms of diabetic lung i......

The Role of Fibroblast Growth Factor 19 in Hepatocellular Carcinoma

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (7)

Hepatocellular carcinoma (HCC) is the fifth most common type of cancer and the third leading cause of cancer-related deaths worldwide. Liver resection......

Nondegradable Collagen Increases Liver Fibrosis but Not Hepatocellular Carcinoma in Mice

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (9)

Although hepatocellular cancer (HCC) usually occurs in the setting of liver fibrosis, the causal relationship between liver fibrosis and HCC is unclea......

Increased M2 Isoform of Pyruvate Kinase in Fibroblasts Contributes to the Growth, Aggressiveness, and Osteoclastogenesis of Odontogenic Keratocysts

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (5)

To investigate the role of glycolysis and the M2 isoform of pyruvate kinase (PKM2) in odontogenic keratocysts (OKCs), the glycolytic flux of primary o......

Loss of Apc Cooperates with Activated Oncogenes to Induce Liver Tumor Formation in Mice

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (5)

Hepatocellular carcinoma (HCC) and hepatoblastoma are the major types of primary liver cancer in adulthood and childhood, respectively. Wnt/B-catenin ......

Promotion of beta-Catenin/Forkhead Box Protein O Signaling Mediates Epithelial Repair in Kidney Injury

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (6)

Fibrosis is characterized by progressively excessive deposition of matrix components and may lead to organ failure. Transforming growth factor-beta (T......

Inhibition of Estrogen-Related Receptor alpha Blocks Liver Steatosis and Steatohepatitis and Attenuates Triglyceride Biosynthesis

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (7)

The estrogen-related receptor (ERR) family of orphan nuclear receptors are transcriptional activators for genes involved in mitochondrial bioenergetic......

A Deep Learning-Based Approach for Glomeruli Instance Segmentation from Multistained Renal Biopsy Pathologic Images

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (8)

Glomeruli instance segmentation from pathologic images is a fundamental step in the automatic analysis of renal biopsies. Glomerular histologic manife......

YAP Accelerates Notch-Driven Cholangiocarcinogenesis via mTORC1 in Mice

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (9)

Intrahepatic cholangiocarcinoma (iCCA) is a lethal malignant neoplasm with limited therapeutic options. Previous studies have found that Notch1 overex......

Human RGR Gene and Associated Features of Age-Related Macular Degeneration in Models of Retina-Choriocapillaris Atrophy

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (8)

Age-related macular degeneration (AMD) is a progressive eye disease and the most common cause of blindness among the elderly. AMD is characterized by ......

Insulin-Induced Gene 2 Expression Is Associated with Breast Cancer Metastasis

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (2)

Insulin-induced gene 2 (INSIG2) functions as a Mocker of cholesterol biosynthesis and has been shown to be involved in colon and pancreatic cancer pat......

Vascular Endothelial Growth Factor Mediates the Sprouted Axonogenesis of Breast Cancer in Rat

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (3)

Nerve infiltration into the tumor is a common feature of the tumor microenvironment. The mechanisms of axonogenesis in breast cancer remain unclear. W......

An RGDKGE-Containing Cryptic Collagen Fragment Regulates Phosphorylation of Large Tumor Suppressor Kinase-1 and Controls Ovarian Tumor Growth by a Yes-Associated Protein-Dependent Mechanism

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (3)

The growth and spread of malignant tumors, such as ovarian carcinomas, are governed in part by complex interconnected signaling cascades occurring bet......

An RGDKGE-Containing Cryptic Collagen Fragment Regulates Phosphorylation of Large Tumor Suppressor Kinase-1 and Controls Ovarian Tumor Growth by a Yes-Associated Protein-Dependent Mechanism

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (3)

The growth and spread of malignant tumors, such as ovarian carcinomas, are governed in part by complex interconnected signaling cascades occurring bet......

Long Noncoding RNA H19 Overexpression Protects against Hypoxic-Ischemic Brain Damage by Inhibiting miR-107 and Up-Regulating Vascular Endothelial Growth Factor

期刊: AMERICAN JOURNAL OF PATHOLOGY, 2021; 191 (3)

Long noncoding RNAs play critical roles in cellular homeostasis, and long noncoding RNA H19 (H19) is implicated in several pathologic conditions. The ......

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