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Glucocorticoids inhibit the maturation of committed osteoblasts via SOX2

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 68 (4)

During bone formation, mesenchymal progenitor cells mature into bone-forming osteoblasts after undergoing several stages of differentiation. Impaired ......

JIF:4.613

Maternal hypothyroidism is associated with M-opsin developmental delay

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 69 (3)

Thyroid hormones are critical for the development of opsins involved in color vision. Hypothyroid mice show delayed M-opsin development and expanded d......

JIF:4.613

A PPAR-alpha agonist and DPP-4 inhibitor mitigate adipocyte dysfunction in obese mice

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 68 (4)

Obesity causes white and brown adipocyte dysfunction, reducing browning and stimulating whitening. Drugs that tackle adipocyte dysfunction through the......

JIF:4.613

Temporal regulation of interferon signalling in human EndoC-beta H1 cells

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 69 (2)

During the development of type 1 diabetes, interferons (IFN) are elaborated from islet-infiltrating immune cells and/or from virally infected beta-cel......

JIF:4.613

Chronicle of a discovery: the retinoic acid receptor

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 69 (4)

The landmark 1987 discovery of the retinoic acid receptor (RAR) came as a surprise, uncovering a genomic kinship between the fields of vitamin A biolo......

JIF:4.613

25 years of ER beta: a personal journey

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 68 (1)

After the discovery of ER beta, a novel role for dihydrotestosterone (DHT) in estrogen signaling was revealed. Instead of just being a better androgen......

JIF:4.613

Retinoic acid receptor structures: the journey from single domains to full-length complex

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 69 (4)

The retinoic acid receptors (RAR alpha, beta, and gamma) are multi-domain polypeptides that heterodimerize with retinoid X receptors (RXR alpha, beta,......

JIF:4.613

Endocrine and metabolic complications of COVID-19: lessons learned and future prospects

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 69 (3)

Coronavirus disease 2019 (COVID-19) is well known for its respiratory complications; however, it can also cause extrapulmonary manifestations, includi......

JIF:4.613

Bone morphogenetic protein 2 controls steroid-induced osteonecrosis of the femoral head via directly inhibiting interleukin-34 expression

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 68 (1)

Increased inflammatory response is one of the major characteristics of osteonecrosis of the femoral head (ONFH). We aimed to investigate the function ......

JIF:4.613

Insulin signaling in the heart is impaired by growth hormone: a direct and early event

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 69 (2)

Growth hormone (GH) exerts major actions in cardiac growth and metabolism. Considering the important role of insulin in the heart and the well-establi......

JIF:4.613

Loss of HOXA10 causes endometrial hyperplasia progressing to endometrial cancer

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 69 (3)

Endometrial cancer is the fourth most common malignancy in women and the precursor lesion is endometrial hyperplasia. HOXA10 is a transcription factor......

JIF:4.613

GPER mediates the IL6/JAK2/STAT3 pathway involved in VEGF expression in swine ovary GCs

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 68 (1)

Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis in ovaries, particularly during follicular development and ovulation. I......

JIF:4.613

Evidence that nuclear receptors are related to terpene synthases

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 68 (3)

Ligand-activated nuclear receptors (NRs) orchestrate development, growth, and reproduction across all animal lifeforms - the Metazoa - but how NRs evo......

JIF:4.613

GCgx: transcriptome-wide exploration of the response to glucocorticoids

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 68 (2)

Glucocorticoids are the cornerstone of immunosuppressive and anti-inflammatory therapy in humans, yet the mechanisms of glucocorticoid immunoregulatio......

JIF:4.613

Female reproductive dysfunctions and the gut microbiota

期刊: JOURNAL OF MOLECULAR ENDOCRINOLOGY, 2022; 69 (3)

The gut microbiome is considered an endocrine organ that can influence distant organs and associated biological pathways. Recent advances suggest that......

JIF:4.613

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