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Patient-specific and gene-corrected induced pluripotent stem cell-derived endothelial cells elucidate single-cell phenotype of pulmonary veno-occlusive disease

期刊: STEM CELL REPORTS, 2022; 17 (12)

Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension characterized by the preferential remodeling of the pulmonary venules......

JIF:6.641

Mechanical force-promoted osteoclastic differentiation via periodontal ligament stem cell exosomal protein ANXA3

期刊: STEM CELL REPORTS, 2022; 17 (8)

Exosomes play a critical role in intracellular communication. The biogenesis and function of exosomes are regulated by multiple biochemical factors. I......

JIF:6.641

Srebflc preserves hematopoietic stem cell function and survival as a switch of mitochondrial metabolism

期刊: STEM CELL REPORTS, 2022; 17 (3)

Mitochondria are fundamental but complex determinants for hematopoietic stem cell (HSC) maintenance. However, the factors involved in the regulation o......

JIF:6.641

The epigenetic state of EED-Gli3-Gli1 regulatory axis controls embryonic cortical neurogenesis

期刊: STEM CELL REPORTS, 2022; 17 (9)

Mutations in the embryonic ectoderm development (EED) cause Weaver syndrome, but whether and how EED affects embryonic brain development remains elusi......

JIF:6.641

Functional redundancy among Polycomb complexes in maintaining the pluripotent state of embryonic stem cells

期刊: STEM CELL REPORTS, 2022; 17 (5)

Polycomb group proteins assemble into multi-protein complexes, known as Polycomb repressive complexes 1 and 2 (PRC1 and PRC2), that guide cell fate de......

JIF:6.641

Generating functional cells through enhanced interspecies chimerism with human pluripotent stem cells

期刊: STEM CELL REPORTS, 2022; 17 (5)

Obtaining functional human cells through interspecies chimerism with human pluripotent stem cells (hPSCs) remains unsuccessful due to its extremely lo......

JIF:6.641

Sleep deprivation induces corneal epithelial progenitor cell over-expansion through disruption of redox homeostasis in the tear film

期刊: STEM CELL REPORTS, 2022; 17 (5)

Sleep deficiency, a common public health problem, causes ocular discomfort and affects ocular surface health. However, the underlying mechanism remain......

JIF:6.641

A human pluripotent stem cell-based model of SARS-CoV-2 infection reveals an ACE2-independent inflammatory activation of vascular endothelial cells through TLR4

期刊: STEM CELL REPORTS, 2022; 17 (3)

To date, the direct causative mechanism of SARS-CoV-2-induced endotheliitis remains unclear. Here, we report that human ECs barely express surface ACE......

JIF:6.641

Mettl14-driven senescence-associated secretory phenotype facilitates somatic cell reprogramming

期刊: STEM CELL REPORTS, 2022; 17 (8)

The METTL3-METTL14 complex, the writer of N-6-methyladenosine (m(6)A), plays an important role in many biological processes. Pre-vious studies have sh......

JIF:6.641

Generation of a TPH2-EGFP reporter cell line for purification and monitoring of human serotonin neurons in vitro and in vivo

期刊: STEM CELL REPORTS, 2022; 17 (10)

Generation of serotonin neurons (SNs) from human pluripotent stem cells (hPSCs) provides a promising platform to explore the mech-anisms of serotonin-......

JIF:6.641

Aberrant nucleosome organization in mouse SCNT embryos revealed by ULI-MNase-seq

期刊: STEM CELL REPORTS, 2022; 17 (7)

Somatic cell nuclear transfer (SCNT) can reprogram terminally differentiated somatic cells into totipotent embryos, but with multiple defects. The nuc......

JIF:6.641

Single-cell spatiotemporal analysis reveals cell fates and functions of transplanted mesenchymal stromal cells during bone repair

期刊: STEM CELL REPORTS, 2022; 17 (10)

Mesenchymal stromal cells (MSCs) transplantation could enhance bone repair. However, the cell fate of transplanted MSCs, in terms of their local distr......

JIF:6.641

UHRF1 interacts with snRNAs and regulates alternative splicing in mouse spermatogonial stem cells

期刊: STEM CELL REPORTS, 2022; 17 (8)

Life-long male fertility relies on exquisite homeostasis and the development of spermatogonial stem cells (SSCs); however, the underlying molecular ge......

JIF:6.641

Differential repression of Otx2 underlies the capacity of NANOG and ESRRB to induce germline entry

期刊: STEM CELL REPORTS, 2022; 17 (1)

Primordial germ cells (PGCs) arise from cells of the post-implantation epiblast in response to cytokine signaling. PGC development can be recapitulate......

JIF:6.641

Involvement of LIN28A in Wnt-dependent regulation of hippocampal neurogenesis in the aging brain

期刊: STEM CELL REPORTS, 2022; 17 (7)

Hippocampal neurogenesis declines with aging. Wnt ligands and antagonists within the hippocampal neurogenic niche regulate the pro-liferation of neura......

JIF:6.641

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