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TAZ maintains telomere length in TNBC cells by mediating Rad51C expression

期刊: BREAST CANCER RESEARCH, 2021; 23 (1)

Background Telomere maintenance is crucial for the unlimited proliferation of cancer cells and essential for the "stemness" of multiple cancer cells. ......

Functional consequences of a rare missense BARD1 c.403G > A germline mutation identified in a triple-negative breast cancer patient

期刊: BREAST CANCER RESEARCH, 2021; 23 (1)

We identified a rare missense germline mutation in BARD1 (c.403G>A or p.Asp135Asn) as pathogenic using integrated genomics and transcriptomics prof......

Progesterone receptor antagonists reverse stem cell expansion and the paracrine effectors of progesterone action in the mouse mammary gland

期刊: BREAST CANCER RESEARCH, 2021; 23 (1)

BackgroundThe ovarian hormones estrogen and progesterone (EP) are implicated in breast cancer causation. A specific consequence of progesterone exposu......

Development and external validation of a breast cancer absolute risk prediction model in Chinese population

期刊: BREAST CANCER RESEARCH, 2021; 23 (1)

Backgrounds In contrast to developed countries, breast cancer in China is characterized by a rapidly escalating incidence rate in the past two decades......

MicroRNA-3613-3p functions as a tumor suppressor and represents a novel therapeutic target in breast cancer

期刊: BREAST CANCER RESEARCH, 2021; 23 (1)

Background MicroRNAs have been reported to participate in tumorigenesis, treatment resistance, and tumor metastasis. Novel microRNAs need to be identi......

PDGFR beta is an essential therapeutic target for BRCA1-deficient mammary tumors

期刊: BREAST CANCER RESEARCH, 2021; 23 (1)

Background: Basal-like breast cancers (BLBCs) are a leading cause of cancer death due to their capacity to metastasize and lack of effective therapies......

Comparative effectiveness of first-line palbociclib plus letrozole versus letrozole alone for HR+/HER2-metastatic breast cancer in US real-world clinical practice

期刊: BREAST CANCER RESEARCH, 2021; 23 (1)

Background Findings from randomized clinical trials may have limited generalizability to patients treated in routine clinical practice. This study exa......

Impact of post-diagnosis weight change on survival outcomes in Black and White breast cancer patients

期刊: BREAST CANCER RESEARCH, 2021; 23 (1)

Purpose To evaluate weight change patterns over time following the diagnosis of breast cancer and to examine the association of post-diagnosis weight ......

MiR-7 reduces the BCSC subset by inhibiting XIST to modulate the miR-92b/Slug/ESA axis and inhibit tumor growth

期刊: BREAST CANCER RESEARCH, 2020; 22 (1)

Background Breast cancer stem cells (BCSCs) are typically seed cells of breast tumor that initiate and maintain tumor growth. MiR-7, as a cancer inhib......

High hepatocyte growth factor expression in primary tumor predicts better overall survival in male breast cancer

期刊: BREAST CANCER RESEARCH, 2020; 22 (1)

Background Breast cancer is rare in men, but management is focused on tumor characteristics commonly found in female breast cancer. The tumor microenv......

Triple-negative breast cancer molecular subtyping and treatment progress

期刊: BREAST CANCER RESEARCH, 2020; 22 (1)

Triple-negative breast cancer (TNBC), a specific subtype of breast cancer that does not express estrogen receptor (ER), progesterone receptor (PR), or......

Immune parameters associated with survival in metaplastic breast cancer

期刊: BREAST CANCER RESEARCH, 2020; 22 (1)

Background Metaplastic breast carcinoma (MBC) is a rare histological type of breast cancer, which commonly shows resistance to standard therapies and ......

Sunitinib facilitates metastatic breast cancer spreading by inducing endothelial cell senescence

期刊: BREAST CANCER RESEARCH, 2020; 22 (1)

Background Sunitinib, a receptor tyrosine kinase (RTK) inhibitor that targets multiple receptors such as vascular endothelial growth factor receptors ......

Local and distant tumor dormancy during early stage breast cancer are associated with the predominance of infiltrating T effector subsets

期刊: BREAST CANCER RESEARCH, 2020; 22 (1)

Background Although breast cancer mortality is a result of distant recurrences associated with the establishment of tumor dormancy, current clinical p......

A comprehensive overview of metaplastic breast cancer: clinical features and molecular aberrations

期刊: BREAST CANCER RESEARCH, 2020; 22 (1)

Metaplastic breast cancer (MpBC) is an exceedingly rare breast cancer variant that is therapeutically challenging and aggressive. MpBC is defined by t......

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