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ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711

期刊: MOLECULAR PSYCHIATRY, 2023; 28 (4)

Amyloid-beta (A beta) deposition in the brain parenchyma is one of the pathological hallmarks of Alzheimer disease (AD). We have previously identified......

GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice

期刊: MOLECULAR PSYCHIATRY, 2023; 28 (7)

Large-scale genome-wide association studies (GWASs) on bipolar disorder (BD) have implicated the involvement of the fatty acid desaturase (FADS) locus......

The molecular pathology of schizophrenia: an overview of existing knowledge and new directions for future research

期刊: MOLECULAR PSYCHIATRY, 2023; 28 (5)

Despite enormous efforts employing various approaches, the molecular pathology in the schizophrenia brain remains elusive. On the other hand, the know......

Characterization of early psychosis patients carrying a genetic vulnerability to redox dysregulation: a computational analysis of mechanism-based gene expression profile in fibroblasts

期刊: MOLECULAR PSYCHIATRY, 2023; 28 (5)

In view of its heterogeneity, schizophrenia needs new diagnostic tools based on mechanistic biomarkers that would allow early detection. Complex inter......

Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits

期刊: MOLECULAR PSYCHIATRY, 2023; 28 (8)

ADNP syndrome, involving the ADNP transcription factor of the SWI/SNF chromatin-remodeling complex, is characterized by developmental delay, intellect......

A systematic review exploring the association between the human gut microbiota and brain connectivity in health and disease

期刊: MOLECULAR PSYCHIATRY, 2023; ()

A body of pre-clinical evidence shows how the gut microbiota influence brain functioning, including brain connectivity. Linking measures of brain conn......

Individual regional associations between Aβ-, tau- and neurodegeneration (ATN) with microglial activation in patients with primary and secondary tauopathies

期刊: MOLECULAR PSYCHIATRY, 2023; 28 (10)

& beta;-amyloid (A & beta;) and tau aggregation as well as neuronal injury and atrophy (ATN) are the major hallmarks of Alzheimer's disease (A......

Impaired functional connectivity of the hippocampus in translational murine models of NMDA-receptor antibody associated neuropsychiatric pathology

期刊: MOLECULAR PSYCHIATRY, 2023; ()

Decreased hippocampal connectivity and disruption of functional networks are established resting-state functional MRI (rs-fMRI) features that are asso......

Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by lithium

期刊: MOLECULAR PSYCHIATRY, 2023; ()

The Shank3 gene encodes the major postsynaptic scaffolding protein SHANK3. Its mutation causes a syndromic form of autism spectrum disorder (ASD): Phe......

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