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Temporally coherent perturbation of neural dynamics during retention alters human multi-item working memory

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 201 ()

Temporarily storing a list of items in working memory (WM), a fundamental ability in cognition, has been posited to rely on the temporal dynamics of m......

Neural circuitry underlying REM sleep: A review of the literature and current concepts

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 204 ()

As one of the fundamental sleep states, rapid eye movement (REM) sleep is believed to be associated with dreaming and is characterized by low-voltage,......

Sodium leak channel contributes to neuronal sensitization in neuropathic pain

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 202 ()

Neuropathic pain affects up to 10 % of the total population and no specific target is ideal for therapeutic need. The sodium leak channel (NALCN), a n......

Repetitive non-invasive prefrontal stimulation reverses neuropathic pain via neural remodelling in mice

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 201 ()

Chronic neuropathic pain presents a major challenge to pharmacological therapy and neurostimulation-based alternatives are gaining interest. Although ......

Dissecting the role of subiculum in epilepsy: Research update and translational potential

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 201 ()

The subiculum serves as the strategic core output of the hippocampus, through which neural activity exits the hippocampal proper and targets the entor......

MicroRNA-96 is required to prevent allodynia by repressing voltage-gated sodium channels in spinal cord

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 202 ()

Voltage-gated sodium channels (Navs) 1.7, 1.8, and 1.9 are predominately expressed in peripheral sensory neurons and are critical for action potential......

DJ-1 in neurodegenerative diseases: Pathogenesis and clinical application

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 204 ()

Neurodegenerative diseases (NDs) are one of the major health threats to human characterized by selective and progressive neuronal loss. The mechanisms......

Functional organization of spatial frequency tuning in macaque V1 revealed with two-photon calcium imaging

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 205 ()

V1 neurons are functionally organized in orientation columns in primates. Whether spatial frequency (SF) columns also exist is less clear because mixe......

Selective optogenetic stimulation of glutamatergic, but not GABAergic, vestibular nuclei neurons induces immediate and reversible postural imbalance in mice

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 204 ()

Glutamatergic and GABAergic neurons represent the neural components of the medial vestibular nuclei. We assessed the functional role of glutamatergic ......

Human hippocampal connectivity is stronger in olfaction than other sensory systems

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 201 ()

During mammalian evolution, primate neocortex expanded, shifting hippocampal functional networks away from primary sensory cortices, towards associati......

Brain preparedness: The proactive role of the cortisol awakening response in hippocampal-prefrontal functional interactions

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 205 ()

Upon awakening from nighttime sleep, the stress hormone cortisol in humans exhibits a robust rise within thirty to forty-five minutes. This cortisol a......

ApoE4 activates C/EBP beta/delta-secretase with 27-hydroxycholesterol, driving the pathogenesis of Alzheimer's disease

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 202 ()

ApoE4, an apolipoprotein implicated in cholesterol transport and amyloid-beta (A beta) metabolism, is a major genetic risk determinant for Alzheimer's......

A gamma-adducin cleavage fragment induces neurite deficits and synaptic dysfunction in Alzheimer's disease

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 203 ()

Neurite deficits and synaptic dysfunction contribute to cognitive impairments in Alzheimer's disease (AD). However, the underlying molecular mechanism......

Delta- and beta-secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 204 ()

Asparagine endopeptidase (AEP), a newly identified delta-secretase, simultaneously cleaves both APP and Tau, promoting Alzheimer's disease (AD) pathol......

Altered striatum centered brain structures in SHANK3 deficient Chinese children with genotype and phenotype profiling

期刊: PROGRESS IN NEUROBIOLOGY, 2021; 200 ()

SHANK3 deficiency represents one of the most replicated monogenic risk factors for autism spectrum disorder (ASD) and SHANK3 caused ASD presents a uni......

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