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circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2

期刊: MOLECULAR CANCER, 2020; 19 (1)

Background Circular RNAs (circRNAs) are a class of noncoding RNAs (ncRNAs) and can modulate gene expression by binding to miRNAs; further, circRNAs ha......

Improving antitumor efficacy via combinatorial regimens of oncolytic virotherapy

期刊: MOLECULAR CANCER, 2020; 19 (1)

As a promising therapeutic strategy, oncolytic virotherapy has shown potent anticancer efficacy in numerous pre-clinical and clinical trials. Oncolyti......

Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit

期刊: MOLECULAR CANCER, 2020; 19 (1)

Background Emerging evidence has shown that circular RNAs (circRNAs) play a crucial regulatory role in the occurrence and development of cancer. Explo......

Exosome-based immunotherapy: a promising approach for cancer treatment

期刊: MOLECULAR CANCER, 2020; 19 (1)

In the era of the rapid development of cancer immunotherapy, there is a high level of interest in the application of cell-released small vesicles that......

Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

期刊: MOLECULAR CANCER, 2020; 19 (1)

Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling embryonic and organ development, as well as cancer pro......

circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway

期刊: MOLECULAR CANCER, 2020; 19 (1)

Background: Laryngeal squamous cell carcinoma (LSCC) is the second most common malignant tumor in head and neck. Autophagy and circular RNAs (circRNAs......

The significance of exosomes in the development and treatment of hepatocellular carcinoma

期刊: MOLECULAR CANCER, 2020; 19 (1)

Hepatocellular carcinoma (HCC) is the most commonmalignancy. Exsome plays a significant role in the elucidation of signal transduction pathways betwee......

m(6)A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

期刊: MOLECULAR CANCER, 2020; 19 (1)

Background Pancreatic cancer is one of the most lethal types of cancer with extremely poor diagnosis and prognosis, and chemo-resistance remains a maj......

A novel IFN alpha-induced long noncoding RNA negatively regulates immunosuppression by interrupting H3K27 acetylation in head and neck squamous cell carcinoma

期刊: MOLECULAR CANCER, 2020; 19 (1)

Background Interferon alpha (IFN alpha) is a well-established regulator of immunosuppression in head and neck squamous cell carcinoma (HNSCC), while t......

Role of HDACs in normal and malignant hematopoiesis

期刊: MOLECULAR CANCER, 2020; 19 (1)

Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of gene expression at each stage of development, and epigenetic ......

TEAD4 modulated LncRNA MNX1-AS1 contributes to gastric cancer progression partly through suppressing BTG2 and activating BCL2

期刊: MOLECULAR CANCER, 2020; 19 (1)

Background Gastric cancer (GC) is the third leading cause of cancer-related mortality globally. Long noncoding RNAs (lncRNAs) are dysregulated in obvi......

Circular RNAs in the tumour microenvironment

期刊: MOLECULAR CANCER, 2020; 19 (1)

Background Circular RNAs (circRNAs) are a new class of endogenous non-coding RNAs (ncRNAs) widely expressed in eukaryotic cells. Mounting evidence has......

lncRNA JPX/miR-33a-5p/Twist1 axis regulates tumorigenesis and metastasis of lung cancer by activating Wnt/beta-catenin signaling

期刊: MOLECULAR CANCER, 2020; 19 (1)

Background MicroRNAs (miRNAs) and Twist1-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination are well established, but the in......

Hypoxia induced LUCAT1/PTBP1 axis modulates cancer cell viability and chemotherapy response

期刊: MOLECULAR CANCER, 2020; 19 (1)

Background Hypoxic tumors are refractory to DNA damage drugs. However, the underlying mechanism has yet to be elucidated. We aimed to identify lncRNAs......

Roles of circRNAs in the tumour microenvironment

期刊: MOLECULAR CANCER, 2020; 19 (1)

The tumour microenvironment (TME) constitutes the area surrounding the tumour during its development and has been demonstrated to play roles in cancer......

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