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ZNF37A promotes tumor metastasis through transcriptional control of THSD4/TGF-beta axis in colorectal cancer

期刊: ONCOGENE, 2021; 40 (19)

Poorly differentiated colorectal cancer (CRC) is characterized by aggressive invasion and stromal fibroblast activation, which results in rapid progre......

LIMK1 promotes peritoneal metastasis of gastric cancer and is a therapeutic target

期刊: ONCOGENE, 2021; 40 (19)

Peritoneal metastasis is a common form of metastasis among advanced gastric cancer patients. In this study, we reported the identification of LIM doma......

MALAT1 modulated FOXP3 ubiquitination then affected GINS1 transcription and drived NSCLC proliferation

期刊: ONCOGENE, 2021; 40 (22)

An increasing number of studies have shown that long-noncoding RNAs (lncRNAs) are involved in the post-translational modifications (PTMs) of protein i......

CTHRC1 promotes liver metastasis by reshaping infiltrated macrophages through physical interactions with TGF-beta receptors in colorectal cancer

期刊: ONCOGENE, 2021; 40 (23)

Metastasis is a major cause of cancer-related deaths. Tumor-intrinsic properties can determine whether tumor metastasis occurs or not. Here, by compar......

ZEB2 facilitates peritoneal metastasis by regulating the invasiveness and tumorigenesis of cancer stem-like cells in high-grade serous ovarian cancers

期刊: ONCOGENE, 2021; 40 (32)

Peritoneal metastasis is a common issue in the progression of high-grade serous ovarian cancers (HGSOCs), yet the underlying mechanism remains unconfi......

Nuclear translocation of ASPL-TFE3 fusion protein creates favorable metabolism by mediating autophagy in translocation renal cell carcinoma

期刊: ONCOGENE, 2021; 40 (18)

The ASPL-TFE3 fusion gene, resulting from t(X;17)(p11.2;q25.3), is one of the most commonly identified fusion genes in Xp11 translocation renal cell c......

Vaccinia-related kinase 2 drives pancreatic cancer progression by protecting Plk1 from Chfr-mediated degradation

期刊: ONCOGENE, 2021; 40 (28)

As a key cell cycle regulator, polo-like kinase 1 (Plk1) has been recognized as a crucial factor involved in the progression of pancreatic cancer (PC)......

Targeting the p300/NONO axis sensitizes melanoma cells to BRAF inhibitors

期刊: ONCOGENE, 2021; 40 (24)

BRAF inhibitors (BRAFi) that target BRAF V600E kinase, a driver mutation found in 50% of melanomas, show a significant antitumor response, but the com......

Nuclear scaffold protein p54(nrb)/NONO facilitates the hypoxia-enhanced progression of hepatocellular carcinoma

期刊: ONCOGENE, 2021; 40 (24)

Hypoxia and related oxidative stress are closely related to the development and treatment of hepatocellular carcinoma (HCC). However, the mechanism me......

Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer

期刊: ONCOGENE, 2021; 40 (31)

Programmed cell death 1 (PD-1) is widely expressed in tumor-infiltrating lymphocytes (TILs) of triple-negative breast cancer (TNBC). As a dominant inh......

LncRNA PINK1-AS promotes G alpha i1-driven gastric cancer tumorigenesis by sponging microRNA-200a

期刊: ONCOGENE, 2021; 40 (22)

Gastric cancer (GC) is one of the leading causes of human mortality around the world. We have previously shown that G alpha i1 (the inhibitory subunit......

C/EBP beta promotes poly(ADP-ribose) polymerase inhibitor resistance by enhancing homologous recombination repair in high-grade serous ovarian cancer

期刊: ONCOGENE, 2021; 40 (22)

PARP inhibitors (PARPi) are efficacious in treating high-grade serous ovarian cancer (HG-SOC) with homologous recombination (HR) deficiency. However, ......

FMR1/circCHAF1A/miR-211-5p/HOXC8 feedback loop regulates proliferation and tumorigenesis via MDM2-dependent p53 signaling in GSCs

期刊: ONCOGENE, 2021; 40 (24)

Glioma is the most common and fatal primary malignant brain tumor. Glioma stem cells (GSCs) may be an important factor in glioma cell proliferation, i......

Targeting HIF-activated collagen prolyl 4-hydroxylase expression disrupts collagen deposition and blocks primary and metastatic uveal melanoma growth

期刊: ONCOGENE, 2021; 40 (33)

Uveal melanoma (UM) is the most prevalent primary intraocular malignancy in adults, and patients that develop metastases (similar to 50%) survive <......

Enhancement of E-cadherin expression and processing and driving of cancer cell metastasis by ARID1A deficiency

期刊: ONCOGENE, 2021; 40 (36)

The ARID1A gene, which encodes a subunit of the SWI/SNF chromatin remodeling complex, has been found to be frequently mutated in many human cancer typ......

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