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Impact of the combined timing of PD-1/PD-L1 inhibitors and chemotherapy on the outcomes in patients with refractory lung cancer

期刊: ESMO OPEN, 2021; 6 (2)

Background: PD-1/PD-L1 inhibitors in combination with chemotherapy are widely used in clinical practice. However, the ideal combined timing of them ha......

Has COVID-19 had a greater impact on female than male oncologists? Results of the ESMO Women for Oncology (W4O) Survey

期刊: ESMO OPEN, 2021; 6 (3)

Background: European Society for Medical Oncology Women for Oncology (ESMO W4O) research has previously shown under-representation of female oncologis......

ATLAS trial of adjuvant axitinib in patients with renal cell carcinoma: subgroup analyses with focus on axitinib dosing and racial groups

期刊: ESMO OPEN, 2021; 6 (3)

Background: The ATLAS trial, investigating adjuvant axitinib versus placebo in renal cell carcinoma (RCC), was stopped for futility at a preplanned in......

SAUL, a single-arm study of atezolizumab for chemotherapy-pretreated locally advanced or metastatic carcinoma of the urinary tract: outcomes by key baseline factors, PD-L1 expression and prior platinum therapy

期刊: ESMO OPEN, 2021; 6 (3)

Background: The impact of pretreatment factors on immune checkpoint inhibition in platinum-refractory advanced urothelial cancer (aUC) deserves furthe......

Prognostic model for risk stratification of de novo metastatic nasopharyngeal carcinoma patients treated with chemotherapy followed by locoregional radiotherapy

期刊: ESMO OPEN, 2021; 6 (1)

Background: There is no clinically applicable prognostic model designed for patients with de novo metastatic nasopharyngeal carcinoma (mNPC) treated w......

Liquid biopsy by combining 5-hydroxymethylcytosine signatures of plasma cell-free DNA and protein biomarkers for diagnosis and prognosis of hepatocellular carcinoma

期刊: ESMO OPEN, 2021; 6 (1)

Background: Liquid biopsy based on 5-hydroxymethylcytosine (5hmC) signatures of plasma cell-free DNA (cfDNA) originating from tumor cells provides a n......

Clinical significance of ERBB2 exon 16 skipping: analysis of a real-world retrospective observational cohort study

期刊: ESMO OPEN, 2020; 5 (6)

Background ERBB2 exon 16 skipping is an alternatively spliced isoform of ERBB2, which was reported to lead to oncogenic activation of ERBB2 and could ......

Prevalence and prognostic impact of comorbidities and peripheral blood indices in sarcomas

期刊: ESMO OPEN, 2020; 5 (6)

Background The prognostic impact of comorbidities in patients with sarcomas is not well defined. The aims of this study were to examine the implicatio......

Machine learning: an approach to preoperatively predict PD-1/PD-L1 expression and outcome in intrahepatic cholangiocarcinoma using MRI biomarkers

期刊: ESMO OPEN, 2020; 5 (6)

Objective To investigate the preoperative predictive value of non-invasive imaging biomarkers for programmed cell death protein 1/programmed cell deat......

Chemotherapy plus bevacizumab as an optimal first-line therapeutic treatment for patients with right-sided metastatic colon cancer: a meta-analysis of first-line clinical trials

期刊: ESMO OPEN, 2020; 5 (2)

Background Monoclonal antibodies of anti-epidermal growth factor receptor (EGFR) have been recommended as first-line therapy for patients with left-si......

Prognostic nomogram based on the metastatic lymph node ratio for gastric neuroendocrine tumour: SEER database analysis

期刊: ESMO OPEN, 2020; 5 (2)

Objective The prediction of survival of gastric neuroendocrine tumours (g-NETs) is controversial. Prognostic effects of the metastatic lymph node rati......

ESMO Clinical Research Observatory (ECRO): improving the efficiency of clinical research through rationalisation of bureaucracy

期刊: ESMO OPEN, 2020; 5 (3)

During the last years, there has been a dramatic increase in the administrative and bureaucratic burden associated with clinical research, which has c......

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