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Efficacy and safety of low-dose IL-2 in the treatment of systemic lupus erythematosus: a randomised, double-blind, placebo-controlled trial

期刊: ANNALS OF THE RHEUMATIC DISEASES, 2020; 79 (1)

Objectives Open-labelled clinical trials suggested that low-dose IL-2 might be effective in treatment of systemic lupus erythematosus (SLE). A double-......

Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy upon microbiome composition

期刊: ANNALS OF THE RHEUMATIC DISEASES, 2020; 79 (1)

Objectives Diverse evidence including clinical, genetic and microbiome studies support a major role of the gut microbiome in the common immune-mediate......

FGFR3 deficiency enhances CXCL12-dependent chemotaxis of macrophages via upregulating CXCR7 and aggravates joint destruction in mice

期刊: ANNALS OF THE RHEUMATIC DISEASES, 2020; 79 (1)

Objectives This study aims to investigate the role and mechanism of FGFR3 in macrophages and their biological effects on the pathology of arthritis. M......

2018 Update of the EULAR recommendations for the management of large vessel vasculitis

期刊: ANNALS OF THE RHEUMATIC DISEASES, 2020; 79 (1)

Background Since the publication of the European League Against Rheumatism (EULAR) recommendations for the management of large vessel vasculitis (LVV)......

Germline genetic patterns underlying familial rheumatoid arthritis, systemic lupus erythematosus and primary Sjogren's syndrome highlight T cell-initiated autoimmunity

期刊: ANNALS OF THE RHEUMATIC DISEASES, 2020; 79 (2)

Objectives Familial aggregation of primary Sjogren's syndrome (pSS), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and co-aggregation ......

Efficacy and safety of ixekizumab through 52 weeks in two phase 3, randomised, controlled clinical trials in patients with active radiographic axial spondyloarthritis (COAST-V and COAST-W)

期刊: ANNALS OF THE RHEUMATIC DISEASES, 2020; 79 (2)

Objectives To investigate the efficacy and safety of ixekizumab for up to 52 weeks in two phase 3 studies of patients with active radiographic axial s......

Single-cell RNA-seq analysis identifies meniscus progenitors and reveals the progression of meniscus degeneration

期刊: ANNALS OF THE RHEUMATIC DISEASES, 2020; 79 (3)

Objectives The heterogeneity of meniscus cells and the mechanism of meniscus degeneration is not well understood. Here, single-cell RNA sequencing (sc......

Elevated EPSTI1 promote B cell hyperactivation through NF-kappa B signalling in patients with primary Sjogren's syndrome

期刊: ANNALS OF THE RHEUMATIC DISEASES, 2020; 79 (4)

Background Primary Sjogren's syndrome (pSS) is a systemic autoimmune disease characterised by aberrant B cell hyperactivation, whose mechanism is part......

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