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ZNF382: A transcription inhibitor down-regulated in multiple tumors due to promoter methylation

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Zinc finger protein 382 (ZNF382), a member of the Kriippel-associated box zinc finger proteins (KRAB-ZFPs) family, plays critical roles in regulating ......

Plasma osteopontin acts as a prognostic marker in acute intracerebral hemorrhage patients

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Background: Osteopontin (OPN), a matricellular protein, is greatly generated from brain tissues after acute brain injury. We determine the relationshi......

Correlation between albumin to fibrinogen ratio, C-reactive protein to albumin ratio and Th17 cells in patients with rheumatoid arthritis

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Background The albumin to fibrinogen ratio (AFR) and the C-reactive protein to albumin ratio (CAR) have been served as inflammatory markers. However, ......

The establishment of CMV antigen-specific enzyme-linked immunospot assay among Chinese: A pilot study

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Background: The prevalence of cytomegalovirus in China is high and the infection could result in disastrous consequences. Cellular immunity is the mai......

Haematologic indices in hepatitis B virus-related liver disease

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Several markers and prognostic scores have been identified for predicting the development and progression of liver disease; among them, haematological......

The first two Chinese Myhre syndrome patients with the recurrent SMAD4 pathogenic variants: Functional consequences and clinical diversity

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Myhre syndrome is a rare autosomal dominant multi-organ disorder characterized by growth retardation, skeletal anomalies, muscular hypertrophy, joint ......

A comparative study on the value of Xpert MTB/RIF and T-SPOT.TB tests in the diagnosis of bone and joint tuberculosis

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Background: We evaluated the application value of Xpert MTB/RIF and T-SPOT.TB in the diagnosis of bone and joint tuberculosis. Methods: One hundred tw......

Long noncoding RNA TP73-AS1 in human cancers

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Long noncoding RNAs (lncRNAs) play an important role in tumor development. With the development of sequencing technology, many new lncRNAs have been d......

Cholesterol in LDL receptor recycling and degradation

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

The SREBP2/LDLR pathway is sensitive to cholesterol content in the endoplasmic reticulum (ER), while membrane low-density lipoprotein receptor (LDLR) ......

Comparison of remnant cholesterol levels estimated by calculated and measured LDL-C levels in Chinese patients with coronary heart disease

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Background: Evidence about whether remnant cholesterol (RC), especially non-fasting RC, is a causal risk factor for coronary heart disease (CHD) in Ch......

Association of serum total fatty acids with type 2 diabetes

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Background: Type 2 diabetes (T2D), a typical metabolic disease, is closely associated with serum free fatty acids. But the association between serum t......

Serum soluble lectin-like oxidized low-density lipoprotein receptor-1 concentrations and prognosis of aneurysmal subarachnoid hemorrhage

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Background: Oxidized low-density lipoprotein (ox-LDL) and its receptor, lectin-like ox-LDL receptor-1 (LOX-1) are involved in the pathogenesis of athe......

Diagnostic performance of HE4 and ROMA among Chinese women

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Objective: Human epididymis protein 4 (HE4) has been suggested as a new biomarker for the detection of ovarian cancer. Because there are few reports o......

Use of a novel index, the A-index, and its associated nomogram to predict overall survival rates after resection of primary hepatocellular carcinoma

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Background: Several international staging or scoring systems don't accurately predict overall survival (OS) after resection of primary hepatocellular ......

Role of miRNA sponges in hepatocellular carcinoma

期刊: CLINICA CHIMICA ACTA, 2020; 500 ()

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. HCC patients are commonly diagnosed at an advanced stage, for wh......

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