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Correlation of Krebs von den Lungen-6 and fibronectin with pulmonary fibrosis in coronavirus disease 2019

期刊: CLINICA CHIMICA ACTA, 2021; 517 ()

Objective: Coronavirus Disease 2019 (COVID-19) caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still spreading worl......

Development of a panel of autoantibody against NSG1 with CEA, CYFRA21-1, and SCC-Ag for the diagnosis of esophageal squamous cell carcinoma

期刊: CLINICA CHIMICA ACTA, 2021; 520 ()

Objective: Development of a panel of serum autoantibody against Neuron specific gene family member 1 (NSG1) with traditional tumor biomarkers of esoph......

Urine organic acid as the first clue towards aromatic L-amino acid decarboxylase (AADC) deficiency in a high prevalence area

期刊: CLINICA CHIMICA ACTA, 2021; 521 ()

Background: Aromatic L-amino acid decarboxylase deficiency is a rare neurometabolic disease due to impaired decarboxylation of neurotransmitter precur......

Novel variants of the PCCB gene in Chinese patients with propionic acidemia

期刊: CLINICA CHIMICA ACTA, 2021; 519 ()

Background and aims: Propionic acidemia (PA) is an autosomal recessive metabolic disorder caused by a deficiency of propionyl-CoA carboxylase and muta......

Identification of three novel pathogenic mutations in sarcomere genes associated with familial hypertrophic cardiomyopathy based on multi-omics study

期刊: CLINICA CHIMICA ACTA, 2021; 520 ()

Background: Familial hypertrophic cardiomyopathy (HCM) is a leading cause of sudden cardiac death, but exhibits heterogeneous clinical features. A maj......

Proteomic screening of potential N-glycoprotein biomarkers for colorectal cancer by TMT labeling combined with LC-MS/MS

期刊: CLINICA CHIMICA ACTA, 2021; 521 ()

Background and aims: Colorectal cancer (CRC) is part of the most widespread malignant tumors. At present, colonoscopy is a routine procedure in the di......

Exosomal analysis: Advances in biosensor technology

期刊: CLINICA CHIMICA ACTA, 2021; 518 ()

Exosomes, a subtype of extracellular vesicle secreted by cells, have been a subject of intense research interest. Unfortunately, a simple and reliable......

Oxidative stress in vascular calcification

期刊: CLINICA CHIMICA ACTA, 2021; 519 ()

Vascular calcification (VC), which is closely associated with significant mortality in cardiovascular disease, chronic kidney disease (CKD), and/or di......

Clinical laboratory evaluation of COVID-19

期刊: CLINICA CHIMICA ACTA, 2021; 519 ()

COVID-19, caused by SARS-CoV-2, is a highly infectious disease, and clinical laboratory detection has played important roles in its diagnosis and in e......

Lipid metabolism changes in patients with severe COVID-19

期刊: CLINICA CHIMICA ACTA, 2021; 517 ()

Background: We investigated the dynamic changes in lipid profiles and their correlations with disease severity and clinical outcome in patients with s......

Anti-IgLON5 disease in a pediatric patient with Langerhans cell histiocytosis

期刊: CLINICA CHIMICA ACTA, 2021; 521 ()

Introduction: Anti-IgLON5 disease is a rare autoimmune disease of the central nervous system. Different from the previous autoimmune encephalitis, the......

Sphingosine 1-phosphate and its receptors in ischemia

期刊: CLINICA CHIMICA ACTA, 2021; 521 ()

Sphingosine 1-phosphate (S1P), a metabolite of sphingolipids, is mainly derived from red blood cells (RBCs), platelets and endothelial cells (ECs). It......

Extracellular vesicle YRNA in atherosclerosis

期刊: CLINICA CHIMICA ACTA, 2021; 517 ()

Atherosclerosis is characterized by lipid accumulation and chronic inflammation. The accumulation of apoptotic foam cells can induce the secretion of ......

The S100 protein family in lung cancer

期刊: CLINICA CHIMICA ACTA, 2021; 520 ()

The S100 protein family is involved in the pathogenesis of several malignancies including lung cancer. Recent studies have shown that one member, S100......

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