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miR-107 regulates the effect of MCM7 on the proliferation and apoptosis of colorectal cancer via the PAK2 pathway

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 190 ()

Microchromosome maintenance protein 7 (MCM7), a DNA replication permitting factor, plays an essential role in initiating DNA replication. MCM7 is repo......

Spleen tyrosine kinase (SYK) inhibitor PRT062607 protects against ovariectomy-induced bone loss and breast cancer-induced bone destruction

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 188 ()

Osteolytic diseases, including breast cancer-induced osteolysis and postmenopausal osteoporosis, are attributed to excessive bone resorption by osteoc......

TGF-beta 1-activated cancer-associated fibroblasts promote breast cancer invasion, metastasis and epithelial-mesenchymal transition by autophagy or overexpression of FAP-alpha

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 188 ()

Cancer-associated fibroblasts (CAFs) play an important role in the initiation, metastasis, and invasion of breast cancer. However, whether autophagy a......

Malayoside, a cardenolide glycoside extracted from Antiaris toxicaria Lesch, induces apoptosis in human non-small lung cancer cells via MAPK-Nur77 signaling pathway

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 190 ()

Lung cancer is the leading cause of cancer deaths in the world. Non-small cell lung cancer (NSCLC), with poor prognosis and resistance to chemoradioth......

Overexpression of retinoid X receptor beta provides protection against oxidized low-density lipoprotein-induced inflammation via regulating PGC1 alpha-dependent mitochondrial homeostasis in endothelial cells

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 188 ()

Retinoid X receptor beta (RXR13) has been poorly studied in atherosclerosis. The aim of the present study is to explore the function of RXR13 in oxidi......

Berberine suppresses bladder cancer cell proliferation by inhibiting JAK1-STAT3 signaling via upregulation of miR-17-5p

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 188 ()

Hyperactivation of signal transducer and activator of transcription 3 (STAT3) is strongly associated with cancer initiation, progression, metastasis, ......

Chemogenetic manipulation of astrocytic activity: Is it possible to reveal the roles of astrocytes?

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 186 ()

Astrocytes are the major glial cells in the central nervous system, but unlike neurons, they do not produce action potentials. For many years, astrocy......

GLP-1 improves the neuronal supportive ability of astrocytes in Alzheimer's disease by regulating mitochondrial dysfunction via the cAMP/PKA pathway

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 188 ()

The glucagon-like peptide-1 (GLP-1) was shown to have neuroprotective effects in Alzheimer's disease (AD). However, the underlying mechanism remains e......

Interpersonal brain synchronization with instructor compensates for learner's sleep deprivation in interactive learning

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 191 ()

Recent advances shifted the focus on single-brain functioning toward two-brain communication during learning interactions, following the demonstration......

Homoharringtonine synergizes with quizartinib in FLT3-ITD acute myeloid leukemia by targeting FLT3-AKT-c-Myc pathway

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 188 ()

Acute myeloid leukemia (AML) with FLT3 internal tandem duplication (FLT3-ITD) has a dismal prognosis. FLT3 inhibitors have been developed to treat pat......

TIMP1 down-regulation enhances gemcitabine sensitivity and reverses chemoresistance in pancreatic cancer

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 189 ()

The therapeutic effect of gemcitabine (GEM) in pancreatic ductal adenocarcinoma (PDAC) is limited due to low drug sensitivity and high drug resistance......

Intestinal guard: Human CXCL17 modulates protective response against mycotoxins and CXCL17-mimetic peptides development

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 188 ()

Mycotoxin contamination is an ongoing and growing issue that can create health risks and even cause death. Unfortunately, there is currently a lack of......

Vincristine leads to colonic myenteric neurons injury via pro-inflammatory macrophages activation

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 186 ()

Vincristine is widely used in treatment of various malignant tumors. The clinical application of vincristine is accompanied by peripheral neurotoxicit......

Intestine-specific FXR agonists as potential therapeutic agents for colorectal cancer

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 186 ()

Colorectal cancer (CRC) is one of the most malignant cancers in the world. A major cause of death in CRC patients is the limited therapeutic options i......

Resveratrol enhances trans-intestinal cholesterol excretion through selective activation of intestinal liver X receptor alpha

期刊: BIOCHEMICAL PHARMACOLOGY, 2021; 186 ()

Resveratrol (RSV) is a dietary polyphenol with well-documented cardio-protective activity, but its effects on blood cholesterol levels remain to be es......

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