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Increased beta-site APP cleaving enzyme 1-mediated insulin receptor cleavage in type 2 diabetes mellitus with cognitive impairment

期刊: ALZHEIMERS & DEMENTIA, 2021; 17 (7)

Introduction Patients with type 2 diabetes mellitus (T2DM) are at a high risk of cognitive impairment, with insulin resistance playing a pivotal role.......

Integrative functional genomic analysis of intron retention in human and mouse brain with Alzheimer's disease

期刊: ALZHEIMERS & DEMENTIA, 2021; 17 (6)

Intron retention (IR) has been implicated in the pathogenesis of complex diseases such as cancers; its association with Alzheimer's disease (AD) remai......

MRI-assessed locus coeruleus integrity is heritable and associated with multiple cognitive domains, mild cognitive impairment, and daytime dysfunction

期刊: ALZHEIMERS & DEMENTIA, 2021; 17 (6)

Introduction: The locus coeruleus (LC) undergoes extensive neurodegeneration in early Alzheimer's disease (AD). The LC is implicated in regulating the......

Association of life-course depression with the risk of dementia in late life: A nationwide twin study

期刊: ALZHEIMERS & DEMENTIA, ; ()

Introduction Whether depression is a prodromal phase or risk factor for dementia is under debate. We aimed to unveil the nature of depression-dementia......

Traditional Chinese medicine for dementia

期刊: ALZHEIMERS & DEMENTIA, ; ()

In Western medicine, dementia refers to a spectrum of diseases affecting cognition, mental health, and physical abilities. Ancient medical literatures......

Blood neuro-exosomal synaptic proteins predict Alzheimer's disease at the asymptomatic stage

期刊: ALZHEIMERS & DEMENTIA, 2021; 17 (1)

Introduction: Exosomes are an emerging candidate for biomarkers of Alzheimer's disease (AD). This study investigated whether exosomal synaptic protein......

Lifestyle, multi-omics features, and preclinical dementia among Chinese: The Taizhou Imaging Study

期刊: ALZHEIMERS & DEMENTIA, 2021; 17 (1)

China has the largest number of patients with dementia in the world. However, dementia in the Chinese population is still poorly understood and under-......

Toward a theory-based specification of non-pharmacological treatments in aging and dementia: Focused reviews and methodological recommendations

期刊: ALZHEIMERS & DEMENTIA, 2021; 17 (2)

Introduction: Non-pharmacological treatments (NPTs) have the potential to improve meaningful outcomes for older people at risk of, or living with deme......

Shared risk and protective factors between Alzheimer's disease and ischemic stroke: A population-based longitudinal study

期刊: ALZHEIMERS & DEMENTIA, 2021; 17 (2)

Introduction: Stroke, especially ischemic stroke's (IS) link with Alzheimer's disease (AD) remains unclear. Methods: This prospective cohort study inc......

Can active life mitigate the impact of diabetes on dementia and brain aging?

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (11)

Introduction: We investigated whether lifelong exposure to stimulating activities (active life, AL) mitigates diabetes-associated dementia risk and br......

PSEN1, PSEN2, and APP mutations in 404 Chinese pedigrees with familial Alzheimer's disease

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (1)

Introduction: The PSENs/APP mutation distribution in Chinese patients with familial Alzheimer's disease (FAD) remains unclear. We aimed to analyze the......

Leisure activity and social integration mitigate the risk of dementia related to cardiometabolic diseases: A population-based longitudinal study

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (2)

Introduction: The effect of comorbid cardiometabolic diseases (CMDs), including diabetes, heart diseases, and stroke, on dementia remains unclear. Met......

Metabolomics and incident dementia in older Chinese adults: The Shanghai Aging Study

期刊: ALZHEIMERS & DEMENTIA, 2020; 16 (5)

Introduction: Metabolomics provide a promising tool to understand the pathogenesis and to identify novel biomarkers of dementia. This study aimed to d......

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