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Combining γ-GT, PIVKA-II, and AFP to predict long-term prognosis in patients with hepatocellular carcinoma after hepatectomy

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (4)

Hepatocellular carcinoma (HCC) is one of the top five contributors to the cancer burden in China, with a poor prognosis and heavy disability-adjusted ......

Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR-194-5p and elevating HK2 expression

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (6)

Osteosarcoma (OS) is the most common bone tumour with a high risk of metastatic progression and recurrence after treatment. Circular RNA hsa_circ_0000......

Circ_0026579 knockdown ameliorates lipopolysaccharide-induced human lung fibroblast cell injury by regulating CXCR1 via miR-370-3p

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (12)

Pneumonia is an inflammatory disease in lower respiratory tracts and its development involves the regulation of RNAs. Circular RNAs are a class of RNA......

Rosmarinic acid protects against lipopolysaccharide-induced cardiac dysfunction via activating Sirt1/PGC-1α pathway to alleviate mitochondrial impairment

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (3)

Sepsis-induced cardiomyopathy is a decisive factor that plays a critical role in the high mortality of septic patients in the critically ill. Mitochon......

Cardioprotective potential of vanillic acid

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (3)

Nowadays, cardiovascular diseases (CVDs) are a global threat to public health, accounting for almost one-third of all deaths worldwide. One of the key......

Ginsenoside Rh4 inhibits the malignant progression of multiple myeloma and induces ferroptosis by regulating SIRT2

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (9)

Multiple myeloma (MM) has a high mortality rate, and the exploration of therapeutic drugs for MM with low side effects is a hot topic at the moment. G......

Fibroblast growth factor 10 ameliorates renal ischaemia-reperfusion injury by attenuating mitochondrial damage

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (1)

Ischaemia-reperfusion (I/R) injury is one of the leading causes of acute kidney injury (AKI). Its pathologic mechanism is quite complex, involving oxi......

Dantrolene and ryanodine receptors in COVID-19: The daunting task and neglected warden

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (5)

Dantrolene (DTN) is a ryanodine receptor (RyR) antagonist that inhibits Ca2+ release from stores in the sarcoplasmic reticulum. DTN is mainly used in ......

An analysis of antithrombotic therapy in elderly patients with atrial fibrillation undergoing percutaneous coronary interventions

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (7)

As a result of large, randomized trials and updates to clinical guidelines, antithrombotic therapy following percutaneous coronary intervention (PCI) ......

Effect of renal denervation on cardiac remodelling and function in rats with chronic intermittent hypoxia

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (9)

Chronic intermittent hypoxia (CIH) mimicking obstructive sleep apnea elicits divergent outcomes in the cardiovascular systems. The effect of renal den......

Potential roles of ellagic acid on metabolic variables in diabetes mellitus: A systematic review

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (2)

Diabetes mellitus is a widespread endocrine disorder globally. Due to its antioxidant and anti-inflammatory properties, ellagic acid has the potential......

Pre-pandemic autonomic function as a predictor of the COVID clinical course in young adults

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (7)

Long coronavirus disease (COVID) is emerging as a common clinical entity in the current era. Autonomic dysfunction is one of the frequently reported p......

CircADSS contributes to hepatocellular carcinoma development by regulating miR-431-5p/TOP2A

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (5)

CircRNAs participated in regulating hepatocellular carcinoma (HCC), and the regulation function of circRNA adenylosuccinate synthase (circADSS) on HCC......

Molecular insight of p53/Sp1/MUC5AC axis in the tumorigenesis and progression of lung adenocarcinoma

期刊: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2023; 50 (1)

The aberrant expression of secretory mucin MUC5AC has been documented during the tumourigenesis and progression of various cancers. However, little is......

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