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SOX18 promotes gastric cancer metastasis through transactivating MCAM and CCL7

期刊: ONCOGENE, 2020; 39 (33)

The therapeutic strategies for advanced gastric cancer (GC) remain unsatisfying and limited. Therefore, it is still imperative to fully elucidate the ......

RNA-binding motif protein 43 (RBM43) suppresses hepatocellular carcinoma progression through modulation of cyclin B1 expression

期刊: ONCOGENE, 2020; 39 (33)

RNA-binding proteins play key roles in the posttranscriptional regulation of mRNA during cancer progression. Here, we show that RNA-binding motif prot......

DNA polymerase beta modulates cancer progression via enhancing CDH13 expression by promoter demethylation

期刊: ONCOGENE, 2020; 39 (33)

DNA polymerase beta (Pol beta) plays a critical role in DNA base excision repair (BER), which is involved in maintaining genomic stability and in the ......

Inhibiting Importin 4-mediated nuclear import of CEBPD enhances chemosensitivity by repression of PRKDC-driven DNA damage repair in cervical cancer

期刊: ONCOGENE, 2020; 39 (34)

Cervical cancer (CC) remains highest in the mortality of female reproductive system cancers, while cisplatin (CDDP) resistance is the one of main reas......

AR-induced long non-coding RNA LINC01503 facilitates proliferation and metastasis via the SFPQ-FOSL1 axis in nasopharyngeal carcinoma

期刊: ONCOGENE, 2020; 39 (34)

Increasing evidence indicates that long non-coding RNAs (lncRNAs) play vital roles in the tumorigenesis and progression of cancers. However, the funct......

LASP1 interacts with N-WASP to activate the Arp2/3 complex and facilitate colorectal cancer metastasis by increasing tumour budding and worsening the pattern of invasion

期刊: ONCOGENE, 2020; 39 (35)

LIM and SH3 protein 1 (LASP1) is a metastasis-related protein reported to enhance tumour progression in colorectal cancer (CRC). However, the underlyi......

Cell-cycle-dependent phosphorylation of RRM1 ensures efficient DNA replication and regulates cancer vulnerability to ATR inhibition

期刊: ONCOGENE, 2020; 39 (35)

Ribonucleotide reductase (RNR) catalyzes the rate-limiting step of de novo synthesis of deoxyribonucleotide triphosphates (dNTPs) building blocks for ......

microRNA-93-5p promotes hepatocellular carcinoma progression via a microRNA-93-5p/MAP3K2/c-Jun positive feedback circuit

期刊: ONCOGENE, 2020; 39 (35)

Cumulative evidence suggests that microRNAs (miRNAs) promote gene expression in cancers. However, the pathophysiologic relevance of miRNA-mediated RNA......

Extracellular ATP promotes breast cancer invasion and chemoresistance via SOX9 signaling

期刊: ONCOGENE, 2020; 39 (35)

Our previous research demonstrated that extracellular adenosine 5 '-triphosphate (ATP) could promote breast cancer cell invasion. However, the impact ......

Viral integration in BK polyomavirus-associated urothelial carcinoma in renal transplant recipients: multistage carcinogenesis revealed by next-generation virome capture sequencing

期刊: ONCOGENE, 2020; 39 (35)

BK polyomavirus (BKPyV)-associated cancer after transplantation has gained increasing attention. However, the role of BKPyV integration on oncogenesis......

Restoring MLL reactivates latent tumor suppression-mediated vulnerability to proteasome inhibitors

期刊: ONCOGENE, 2020; 39 (36)

MLL undergoes multiple distinct chromosomal translocations to yield aggressive leukemia with dismal outcomes. Besides their well-established role in l......

Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation

期刊: ONCOGENE, 2020; 39 (36)

PI3K/Akt/mTOR signaling pathway activity is highly elevated in glioblastoma (GBM). Although rapamycin is known to inhibit this pathway, GBM patients a......

ISL2 modulates angiogenesis through transcriptional regulation of ANGPT2 to promote cell proliferation and malignant transformation in oligodendroglioma

期刊: ONCOGENE, 2020; 39 (37)

Oligodendroglioma is an important type of lower-grade glioma (LGG), which is a slowly progressing brain tumor. Many LGGs eventually transform into a m......

DOCK6 promotes chemo- and radioresistance of gastric cancer by modulating WNT/beta-catenin signaling and cancer stem cell traits

期刊: ONCOGENE, 2020; 39 (37)

Gastric cancer (GC) is the third leading cause of cancer-related mortality worldwide and prognosis after potentially curative gastrectomy remains poor......

TET1 downregulates epithelial-mesenchymal transition and chemoresistance in PDAC by demethylating CHL1 to inhibit the Hedgehog signaling pathway

期刊: ONCOGENE, 2020; 39 (36)

Chemoresistance is a major obstacle to prolonging pancreatic ductal adenocarcinoma (PDAC) patient survival. TET1 is identified as the most important e......

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