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H2O2 enhances the anticancer activity of TMPyP4 by ROS-mediated mitochondrial dysfunction and DNA damage

期刊: MEDICAL ONCOLOGY, 2021; 38 (6)

Cancer is one of the diseases that threatens human health and is a leading cause of mortality worldwide. High levels of reactive oxygen species (ROS) ......

SNRPB is a mediator for cellular response to cisplatin in non-small-cell lung cancer

期刊: MEDICAL ONCOLOGY, 2021; 38 (5)

The small nuclear ribonucleoprotein polypeptides B And B ' (SNRPB) is a core component of spliceosome and plays a key role in pre-mRNA splicing. Emerg......

The novel LSD1 inhibitor ZY0511 suppresses diffuse large B-cell lymphoma proliferation by inducing apoptosis and autophagy

期刊: MEDICAL ONCOLOGY, 2021; 38 (10)

Lysine-specific demethylase 1 (LSD1, also known as KDM1A) is an attractive agent for treatment of cancer. However, the anti-tumor effect of LSD1 inhib......

Resistin increases cisplatin-induced cytotoxicity in lung adenocarcinoma A549 cells via a mitochondria-mediated pathway

期刊: MEDICAL ONCOLOGY, 2021; 38 (6)

Lung cancer is the most commonly diagnosed cancer with a high mortality rate. Cisplatin is one of the most important chemotherapeutic agents for the t......

Computational study on novel natural inhibitors targeting BCL2

期刊: MEDICAL ONCOLOGY, 2021; 38 (8)

Ideal lead compounds and candidate drugs with inhibitory effect on BCL2 were screened from ZINC database, which laid a foundation for drug development......

Identification of the role of mono-ADP-ribosylation in colorectal cancer by integrated transcriptome analysis

期刊: MEDICAL ONCOLOGY, 2021; 38 (9)

Our previous study clarified the carcinogenic properties of arginine-specific mono-ADP-ribosyltransferase 1 (ART1), which results in a critical post-t......

Diosmetin induces apoptosis in ovarian cancer cells by activating reactive oxygen species and inhibiting the Nrf2 pathway

期刊: MEDICAL ONCOLOGY, 2021; 38 (5)

The fatality rate of ovarian cancer ranks first among gynecological tumors, and the prognosis is poor. Diosmetin (Dio), a natural flavonoid obtained f......

ceRNA network development and tumor-infiltrating immune cell analysis in hepatocellular carcinoma

期刊: MEDICAL ONCOLOGY, 2021; 38 (7)

Hepatocellular carcinoma (HCC) is among the primary causes of cancer deaths globally. Despite efforts to understand liver cancer, its high morbidity a......

Systematic identification of the cancer pathways and molecules related with breast cancer immunogenicity

期刊: MEDICAL ONCOLOGY, 2021; 38 (7)

To identify molecular features related to immunogenic activity in breast cancer (BC) and provide new targets and directions for BC immunotherapy, we f......

MPI-based bioinformatic analysis and co-inhibitory therapy with mannose for oral squamous cell carcinoma

期刊: MEDICAL ONCOLOGY, 2021; 38 (9)

Mannose induces tumor cell apoptosis and inhibits glucose metabolism by accumulating intracellularly as mannose 6-phosphate while the drug sensitivity......

The CXCL12/CXCR7 signalling axis promotes proliferation and metastasis in cervical cancer

期刊: MEDICAL ONCOLOGY, 2021; 38 (5)

C-X-C chemokine receptor 7 (CXCR7), a novel receptor of C-X-C motif chemokine ligand 12 (CXCL12), is associated with the occurrence and metastasis of ......

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