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Clinical characteristics and prognosis of patients with isolated thrombotic vs. obstetric antiphospholipid syndrome: a prospective cohort study

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

Background Several studies suggested that thrombotic and obstetric antiphospholipid syndromes could be independent identities, but few have systematic......

Total metabolic lesion volume of lymph nodes measured by F-18-FDG PET/CT: a new predictor of macrophage activation syndrome in adult-onset Still's disease

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

Background To investigate the potential utility of quantitative parameters obtained by F-18-fluorodeoxyglucose positron emission tomography/computed t......

Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-kappa B pathways

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

Background To investigate the role and regulatory mechanisms of fargesin, one of the main components of Magnolia fargesii, in macrophage reprogramming......

High incidence and mortality of Pneumocystis jirovecii infection in anti-MDA5-antibody-positive dermatomyositis: experience from a single center

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

Background Idiopathic inflammatory myopathies (IIM) are associated with a significantly higher risk of opportunistic infections including Pneumocystis......

Age at menarche, age at natural menopause, and risk of rheumatoid arthritis - a Mendelian randomization study

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

Background Hormonal reproductive factors have been suggested to play an important role in the etiology of rheumatoid arthritis (RA), an autoimmune inf......

Esophagus involvement in systemic sclerosis: ultrasound parameters and association with clinical manifestations

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

Background The esophagus involvement in systemic sclerosis (SSc) is very common yet underestimated due to the lack of suitable screening tools. This s......

Microarray-based analysis of renal complement components reveals a therapeutic target for lupus nephritis

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

Background Screening abnormal pathways and complement components in the kidneys of patients with lupus nephritis (LN) and NZB/W mice may help to ident......

Lactate oxidative phosphorylation by annulus fibrosus cells: evidence for lactate-dependent metabolic symbiosis in intervertebral discs

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

Background Intervertebral disc degeneration contributes to low back pain. The avascular intervertebral disc consists of a central hypoxic nucleus pulp......

Cluster analysis of phenotypes of patients with Behcet's syndrome: a large cohort study from a referral center in China

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

IntroductionBehcet's syndrome (BS) is a complex, heterogeneous disorder. However, classification of its subgroups is still debated. The purpose of thi......

Clinical characteristics, imaging phenotypes and events free survival in Takayasu arteritis patients with hypertension

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

Background Hypertension occurred in 30-80% of Takayasu arteritis (TAK) patients around the world and the occurrence of hypertension might worsen the d......

Clinical characteristics and outcome of IgG4-related disease with hypocomplementemia: a prospective cohort study

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

Background Immunoglobulin G4-related disease (IgG4-RD) is a newly recognized systemic, immune-mediated, and fibro-inflammatory disease. Hypocomplement......

Bone mineral density and microarchitecture among Chinese patients with rheumatoid arthritis: a cross-sectional study with HRpQCT

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

Background Patients with rheumatoid arthritis (RA) are at increased risk of fractures. Although their decline in bone mineral density (BMD) is well-es......

Polysaccharide from Angelica sinensis attenuates SNP-induced apoptosis in osteoarthritis chondrocytes by inducing autophagy via the ERK1/2 pathway

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

ObjectiveChondrocyte apoptosis plays a vital role in osteoarthritis (OA) progression. Angelica sinensis polysaccharide (ASP), a traditional Chinese me......

Therapeutic potential of targeting Tfr/Tfh cell balance by low-dose-IL-2 in active SLE: a post hoc analysis from a double-blind RCT study

期刊: ARTHRITIS RESEARCH & THERAPY, 2021; 23 (1)

Objective: To investigate the regulation of T follicular regulatory (Tfr) and T follicular (Tfh) cell subtypes by low-dose IL-2 in systemic lupus eryt......

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