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Converting primary tumor towards an in situ STING-activating vaccine via a biomimetic nanoplatform against recurrent and metastatic tumors

期刊: NANO TODAY, 2021; 38 ()

Currently, vaccine is a promising tumor prevention modality in cancer therapy. However, it is hard to elicit robust antitumor immunity in patients alr......

Enantiomeric alkynyl-protected Au-10 clusters with chirality-dependent radiotherapy enhancing effects

期刊: NANO TODAY, 2021; 39 ()

Due to the homo-chirality preference of human body to most of chiral species, synthesizing enantiopure drugs and investigating the pharmacological act......

Dual-functional super bispecific nano-antibodies derived from monoclonal antibodies potentiate the antitumor effect of innate immune cells

期刊: NANO TODAY, 2021; 39 ()

Innate immune cells, including natural killer cells and macrophages, are crucial in tumor surveillance and elimination. In contrast to the relatively ......

Boosting innate and adaptive antitumor immunity via a biocompatible and carrier-free nanovaccine engineered by the bisphosphonates-metal coordination

期刊: NANO TODAY, 2021; 37 ()

Most of tumor vaccines currently focus on inducing adaptive immunity, while the antitumor potential of innate immunity is getting more attentions. In ......

Fullerenols boosting the therapeutic effect of anti-CD47 antibody to trigger robust anti-tumor immunity by inducing calreticulin exposure

期刊: NANO TODAY, 2021; 37 ()

Phagocyte-mediated programmed cell removal (PrCR) plays an important role in the immunosurveillance and elimination of cancer cells. The induction of ......

Precise tailoring of multiple nanostructures based on atomic layer assembly via versatile soft-templates

期刊: NANO TODAY, 2021; 38 ()

Nanodevices have higher requirements for nanofabrication in tuning the size, shape and spatial arrangement of nanostructures and their assemblies in n......

Recent advances in enhanced chemodynamic therapy strategies

期刊: NANO TODAY, 2021; 39 ()

Chemodynamic therapy (CDT) is a novel therapeutic modality that employs Fenton or Fenton-like reactions to destroy cancer cells via the disproportiona......

Biodegradable hydrogel with thermo-response and hemostatic effect for photothermal enhanced anti-infective therapy

期刊: NANO TODAY, 2021; 39 ()

Massive bleeding and infectious complication remain the leading cause of worldwide trauma deaths. To tackle this issue, a platelet-inspired degradable......

Radionuclide labeled gold nanoclusters boost effective anti-tumor immunity for augmented radio-immunotherapy of cancer

期刊: NANO TODAY, 2021; 38 ()

Given the complexity, heterogeneity and metastasis of patient tumors, the combined therapy is usually applied in clinical applications. Internal radio......

Overcoming immune resistance by sequential prodrug nanovesicles for promoting chemoimmunotherapy of cancer

期刊: NANO TODAY, 2021; 36 ()

Chemotherapy by certain types of anticancer drugs (e.g., doxorubicin (DOX) and oxaliplatin (OXA)) can elicit antitumor immune response by promoting im......

Fe3O4@Pt nanozymes combining with CXCR4 antagonists to synergistically treat acute myeloid leukemia

期刊: NANO TODAY, 2021; 37 ()

Recurrence and drug resistance of acute myeloid leukemia (AML) remained the leading causes of death in blood cancers. The interaction of chemokine rec......

Nanobooster-encapsulated hybrid RNA as anti-tumor viral mimicry

期刊: NANO TODAY, 2021; 38 ()

Innate sensing of viral RNA analogs represents a promising tool for cancer intervention, yet the tumor microenvironment (TME) renders tumor cells and ......

Bio-based nanomaterials for cancer therapy

期刊: NANO TODAY, 2021; 38 ()

Bio-based nanomaterials have received considerable attention in cancer therapies due to their potent characteristics such as autologous pharmaceutical......

Biomimetic sonodynamic therapy-nanovaccine integration platform potentiates Anti-PD-1 therapy in hypoxic tumors

期刊: NANO TODAY, 2021; 38 ()

Immune checkpoint blockade (ICB) therapy has emerged as novel therapeutic modality for hard-to-treat solid tumors. However, inadequate T cell infiltra......

Single injection and multiple treatments: An injectable nanozyme hydrogel as AIEgen reservoir and release controller for efficient tumor therapy

期刊: NANO TODAY, 2021; 37 ()

Direct intratumoral injection of aggregation-induced emission luminogen (AIEgen) enable direct photodynamic therapy (PDT) of tumors, but these injecti......

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