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Novel Lytic Phages Protect Cells and Mice against Pseudomonas aeruginosa Infection

期刊: JOURNAL OF VIROLOGY, 2021; 95 (8)

With the fast emergence of serious antibiotic resistance and the lagging discovery of novel antibacterial drugs, phage therapy for pathogenic bacteria......

HIV-1 Uses Dynamic Podosomes for Entry into Macrophages

期刊: JOURNAL OF VIROLOGY, 2021; 95 (10)

Macrophages are one of the major targets of human immunodeficiency virus 1 (HIV-1) and play crucial roles in viral dissemination and persistence durin......

Respiratory Syncytial Virus Activates Rab5a To Suppress IRF1-Dependent Lambda Interferon Production, Subverting the Antiviral Defense of Airway Epithelial Cells

期刊: JOURNAL OF VIROLOGY, 2021; 95 (8)

The limited antiviral options and lack of an effective vaccine against human respiratory syncytial virus (RSV) highlight the need for a novel antivira......

Potent Neutralization of SARS-CoV-2 by Hetero-Bivalent Alpaca Nanobodies Targeting the Spike Receptor-Binding Domain

期刊: JOURNAL OF VIROLOGY, 2021; 95 (10)

Cellular entry of SARS-CoV-2 requires the binding between the receptor-binding domain (RBD) of the viral Spike protein and the cellular angiotensin-co......

Trypsin-Enhanced Infection with Porcine Epidemic Diarrhea Virus Is Determined by the S2 Subunit of the Spike Glycoprotein

期刊: JOURNAL OF VIROLOGY, 2021; 95 (11)

Porcine epidemic diarrhea virus (PEDV) is an enteric pathogen of importance to the swine industry, causing high mortality in neonatal piglets. Efficie......

The Furin-S2 ' Site in Avian Coronavirus Plays a Key Role in Central Nervous System Damage Progression

期刊: JOURNAL OF VIROLOGY, 2021; 95 (11)

The furin cleavage site plays an important role in virus pathogenicity. The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV......

Cryo-electron Microscopy Structure of S-Trimer, a Subunit Vaccine Candidate for COVID-19

期刊: JOURNAL OF VIROLOGY, 2021; 95 (11)

Within a year after its emergence, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected over 100 million people worldwide, with a......

Nonsegmented Negative-Sense RNA Viruses Utilize N-6-Methyladenosine (m(6)A) as a Common Strategy To Evade Host Innate Immunity

期刊: JOURNAL OF VIROLOGY, 2021; 95 (9)

N-6-Methyladenosine (m(6)A) is the most abundant internal RNA modifica-tion catalyzed by host RNA methyltransferases. As obligate intracellular parasi......

Interferon Inducer IFI35 Regulates RIG-I-Mediated Innate Antiviral Response through Mutual Antagonism with Influenza Virus Protein NS1

期刊: JOURNAL OF VIROLOGY, 2021; 95 (11)

Interferon-stimulated genes (ISGs) create multiple lines of defense against viral infection. Here, we show that interferon-induced protein 35 (IFI35) ......

Reassortment and Persistence of Influenza A Viruses from Diverse Geographic Origins within Australian Wild Birds: Evidence from a Small, Isolated Population of Ruddy Turnstones

期刊: JOURNAL OF VIROLOGY, 2021; 95 (9)

Australian lineages of avian influenza A viruses (AIVs) are thought to be phylogenetically distinct from those circulating in Eurasia and the Americas......

T Cell Epitope Screening of Epstein-Barr Virus Fusion Protein gB

期刊: JOURNAL OF VIROLOGY, 2021; 95 (10)

Glycoprotein B (gB) is an essential fusion protein for Epstein-Barr virus (EBV) infection of both B cells and epithelial cells and is thus a promising......

Link between Interleukin-23 and Anti-CD4 Autoantibody Production in Antiretroviral-Treated HIV-Infected Individuals

期刊: JOURNAL OF VIROLOGY, 2021; 95 (11)

Potential mechanisms of poor CD4(+) T cell reconstitution after viral suppression with antiretroviral therapy (ART) in HIV disease have been extensive......

Porcine Epidemic Diarrhea Virus Infection Induces Caspase-8-Mediated G3BP1 Cleavage and Subverts Stress Granules To Promote Viral Replication

期刊: JOURNAL OF VIROLOGY, 2021; 95 (9)

Porcine epidemic diarrhea virus (PEDV) is an alpha-coronavirus causing severe diarrhea and high mortality rates in suckling piglets and posing signifi......

pH-Induced Conformational Changes of Human Bocavirus Capsids

期刊: JOURNAL OF VIROLOGY, 2021; 95 (8)

Human bocavirus 1 (HBoV1) and HBoV2 to-4 infect children and immunocompromised individuals, resulting in respiratory and gastrointestinal infections, ......

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