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Prognostic Autophagy-Related Model Revealed by Integrating Single-Cell RNA Sequencing Data and Bulk Gene Profiles in Gastric Cancer

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 9 ()

Autophagy has been associated with tumor progression, prognosis, and treatment response. However, an autophagy-related model and their clinical signif......

JIF:5.868

SIPA1 Enhances Aerobic Glycolysis Through HIF-2 alpha Pathway to Promote Breast Cancer Metastasis

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 9 ()

Increased dependence on aerobic glycolysis is characteristic of most cancer cells, whereas the mechanism underlying the promotion of aerobic glycolysi......

JIF:5.868

MFG-E8 Maintains Cellular Homeostasis by Suppressing Endoplasmic Reticulum Stress in Pancreatic Exocrine Acinar Cells

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 9 ()

Excessive endoplasmic reticulum (ER) stress contributes significantly to the pathogenesis of exocrine acinar damage in acute pancreatitis. Our previou......

JIF:5.868

sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 9 ()

Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the ......

JIF:5.868

An Iron Metabolism-Related Gene Signature for the Prognosis of Colon Cancer

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 9 ()

As an essential microelement, the iron ion is involved in cell proliferation, metabolism, and differentiation. Iron metabolism plays a crucial role in......

JIF:5.868

The Role and Therapeutic Value of Syndecan-1 in Cancer Metastasis and Drug Resistance

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 9 ()

Metastasis and relapse are major causes of cancer-related fatalities. The elucidation of relevant pathomechanisms and adoption of appropriate counterm......

JIF:5.868

Mapk14 is a Prognostic Biomarker and Correlates with the Clinicopathological Features and Immune Infiltration of Colorectal Cancer

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 10 ()

Background: Colorectal cancer (CRC) is one of the most common gastrointestinal tumors, ranking in the top 5 of all common tumors in terms of incidence......

JIF:5.868

The Effect of Temperature on Gonadal Sex Differentiation of Yesso Scallop Patinopecten yessoensis

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 9 ()

Many marine organisms are generally poikilotherms, making seawater temperature one of the most important environmental factors affecting gonadal sex d......

JIF:5.868

A Ferroptosis-Related Gene Prognostic Index to Predict Temozolomide Sensitivity and Immune Checkpoint Inhibitor Response for Glioma

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 9 ()

Background: Gliomas are highly lethal brain tumors. Despite multimodality therapy with surgery, radiotherapy, chemotherapy, and immunotherapy, glioma ......

JIF:5.868

Analysis of m6A Methylation Modification Patterns and Tumor Immune Microenvironment in Breast Cancer

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 10 ()

Increasing evidence indicates that the abnormal expression of N6-methyladenosine (m6A) modification is closely related to the epigenetic regulation of......

JIF:5.868

Gradients of PI(4,5)P-2 and PI(3,5)P-2 Jointly Participate in Shaping the Back State of Dictyostelium Cells

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 10 ()

Polarity, which refers to the molecular or structural asymmetry in cells, is essential for diverse cellular functions. Dictyostelium has proven to be ......

JIF:5.868

GABAergic System Dysfunction in Autism Spectrum Disorders

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 9 ()

Autism spectrum disorder (ASD) refers to a series of neurodevelopmental diseases characterized by two hallmark symptoms, social communication deficits......

JIF:5.868

G alpha(12) and G alpha(13): Versatility in Physiology and Pathology

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 10 ()

G protein-coupled receptors (GPCRs), as the largest family of receptors in the human body, are involved in the pathological mechanisms of many disease......

JIF:5.868

Extracellular Vesicles: The Landscape in the Progression, Diagnosis, and Treatment of Triple-Negative Breast Cancer

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 10 ()

Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer (BC) with diverse biological behavior, high aggressiveness, and poor ......

JIF:5.868

Promoter Hypomethylation of TGFBR3 as a Risk Factor of Alzheimer's Disease: An Integrated Epigenomic-Transcriptomic Analysis

期刊: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022; 9 ()

Alzheimer's disease (AD) is characterized by the abnormal deposition of amyloid-beta (A beta) plaques and tau tangles in the brain and accompanied wit......

JIF:5.868

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