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When cell death goes wrong: inflammatory outcomes of failed apoptosis and mitotic cell death

期刊: CELL DEATH AND DIFFERENTIATION, 2023; 30 (2)

Apoptosis is a regulated cellular pathway that ensures that a cell dies in a structured fashion to prevent negative consequences for the tissue or the......

Caspase-8 is required for HSV-1-induced apoptosis and promotes effective viral particle release via autophagy inhibition

期刊: CELL DEATH AND DIFFERENTIATION, 2023; 30 (4)

Regulated cell death (RCD) plays an important role in the progression of viral replication and particle release in cells infected by herpes simplex vi......

To not love thy neighbor: mechanisms of cell competition in stem cells and beyond

期刊: CELL DEATH AND DIFFERENTIATION, 2023; 30 (4)

Cell competition describes the process in which cells of greater fitness are capable of sensing and instructing elimination of lesser fit mutant cells......

The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2δ transcriptional cascade

期刊: CELL DEATH AND DIFFERENTIATION, 2023; 30 (6)

At the top of the midbrain is the inferior colliculus (IC), which functions as the major hub for processing auditory information. Despite the function......

Mechanisms controlling plant proteases and their substrates

期刊: CELL DEATH AND DIFFERENTIATION, 2023; 30 (4)

In plants, proteolysis is emerging as an important field of study due to a growing understanding of the critical involvement of proteases in plant cel......

Ferroptosis and pyroptosis signatures in critical COVID-19 patients

期刊: CELL DEATH AND DIFFERENTIATION, 2023; 30 (9)

Critical COVID-19 patients admitted to the intensive care unit (ICU) frequently suffer from severe multiple organ dysfunction with underlying widespre......

Cell death and inflammation during obesity: Know my methods, WAT(son)

期刊: CELL DEATH AND DIFFERENTIATION, 2023; 30 (2)

Obesity is a state of low-grade chronic inflammation that causes multiple metabolic diseases. During obesity, signalling via cytokines of the TNF fami......

General transcription factor TAF4 antagonizes epigenetic silencing by Polycomb to maintain intestine stem cell functions

期刊: CELL DEATH AND DIFFERENTIATION, 2023; 30 (3)

Taf4 (TATA-box binding protein-associated factor 4) is a subunit of the general transcription factor TFIID, a component of the RNA polymerase II pre-i......

Mitochondria and cell death-associated inflammation

期刊: CELL DEATH AND DIFFERENTIATION, 2023; 30 (2)

Mitochondria have recently emerged as key drivers of inflammation associated with cell death. Many of the pro-inflammatory pathways activated during c......

Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation

期刊: CELL DEATH AND DIFFERENTIATION, 2023; 30 (2)

Oncogenic KRAS is the key driver oncogene for several of the most aggressive human cancers. One key feature of oncogenic KRAS expression is an early i......

Remembering foods and foes: emerging principles of transcriptional memory

期刊: CELL DEATH AND DIFFERENTIATION, 2023; ()

Transcriptional memory is characterized by a primed cellular state, induced by an external stimulus that results in an altered expression of primed ge......

Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers

期刊: CELL DEATH AND DIFFERENTIATION, 2023; 30 (1)

Despite being frequently observed in cancer cells, chromosomal instability (CIN) and its immediate consequence, aneuploidy, trigger adverse effects on......

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