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Noradrenergic Enhancement of Motor Learning, Attention, and Working Memory in Humans

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2021; 24 (6)

Background: Noradrenaline has an important role as a neuromodulator of the central nervous system. Noradrenergic enhancement was recently shown to enh......

Genetically Determined Levels of Serum Metabolites and Risk of Neuroticism: A Mendelian Randomization Study

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2021; 24 (1)

Background: Neuroticism is a strong predictor for a variety of social and behavioral outcomes, but the etiology is still unknown. Our study aims to pr......

Neuroinflammation Induction and Alteration of Hippocampal Neurogenesis in Mice Following Developmental Exposure to Gossypol

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2021; 24 (5)

Background: Neurogenesis in the neonatal period involves the proliferation and differentiation of neuronal stem/progenitor cells and the establishment......

Albiflorin Attenuates Mood Disorders Under Neuropathic Pain State by Suppressing the Hippocampal NLRP3 Inflammasome Activation During Chronic Constriction Injury

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2021; 24 (1)

Background: Neuropathic pain is a multifaceted and ubiquitous disease across the globe. Mood disorders, such as anxiety and depression, are frequently......

Brain Activity of Benzoate, a D-Amino Acid Oxidase Inhibitor, in Patients With Mild Cognitive Impairment in a Randomized, Double-Blind, Placebo Controlled Clinical Trial

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2021; 24 (5)

Background: Current anti-dementia drugs cannot benefit mild cognitive impairment (MCI). Sodium benzoate (a D-amino acid oxidase [DAO] inhibitor) has b......

Neurons and Astrocytes in Ventrolateral Periaqueductal Gray Contribute to Restraint Water Immersion Stress-Induced Gastric Mucosal Damage via the ERK1/2 Signaling Pathway

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2021; 24 (8)

Background: The restraint water immersion stress (RWIS) model includes both psychological and physical stimulation, which may lead to gastrointestinal......

Behavioral Deficits Induced by Somatostatin-Positive GABA Neuron Silencing Are Rescued by Alpha 5 GABA-A Receptor Potentiation

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2021; 24 (6)

Introduction: Deficits in somatostatin-positive gamma-aminobutyric acid interneurons (SST+ GABA cells) are commonly reported in human studies of mood ......

Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/Caspase-1/GSDMD Pathway in MPTP-Induced Mice Model of Parkinson's Disease

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2020; 23 (11)

Background: Inflammasome-induced neuroinflammation is a major pathogenic mechanism underlying the degeneration of nigral dopaminergic neurons in Parki......

Differences in Executive Function Among Patients With Schizophrenia, Their Unaffected First-Degree Relatives, and Healthy Participants

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2020; 23 (11)

Background: Patients with schizophrenia (SCZ) display impaired executive functions compared with healthy controls (HCs). Furthermore, unaffected first......

The Role of Bacteria and Its Derived Metabolites in Chronic Pain and Depression: Recent Findings and Research Progress

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2020; 23 (1)

Background: Chronic pain is frequently comorbid with depression in clinical practice. Recently, alterations in gut microbiota and metabolites derived ......

Analysis of Time-Course, Dose-Effect, and Influencing Factors of Antidepressants in the Treatment of Acute Adult Patients With Major Depression

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2020; 23 (2)

Objective: Model-based meta-analysis was used to describe the time-course and dose-effect relationships of antidepressants and also simultaneously inv......

Prenatal Exposure to Ketamine Leads to Anxiety-Like Behaviors and Dysfunction in Bed Nucleus of Stria Terminalis

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2020; 23 (3)

Background: Both the clinical and preclinical studies have suggested embryonic or infant exposure to ketamine, a general anesthetic, pose a great thre......

Polygenetic Risk Scores for Major Psychiatric Disorders Among Schizophrenia Patients, Their First-Degree Relatives, and Healthy Participants

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2020; 23 (3)

Background: The genetic etiology of schizophrenia (SCZ) overlaps with that of other major psychiatric disorders in samples of European ancestry. The p......

Epigenetic Modifications of GABAergic Interneurons Contribute to Deficits in Adult Hippocampus Neurogenesis and Depression-Like Behavior in Prenatally Stressed Mice

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2020; 23 (4)

Background: Prenatal stress (PRS) is considered a risk factor for depressive disorder. Adult hippocampal neurogenesis is believed to play a role in th......

Upregulation of TRPC6 Mediated by PAX6 Hypomethylation Is Involved in the Mechanical Allodynia Induced by Chemotherapeutics in Dorsal Root Ganglion

期刊: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2020; 23 (4)

Background: Although the action mechanism of antineoplastic agents is different, oxaliplatin, paclitaxel, or bortezomib as first-line antineoplastic d......

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