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Translation Rescue by Targeting Ppp1r15a through Its Upstream Open Reading Frame in Sepsis-Induced Acute Kidney Injury in a Murine Model

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2023; 34 (2)

Background Translation shutdown is a hallmark of late-phase, sepsis-induced kidney injury. Methods for controlling protein synthesis in the kidney are......

Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2023; 34 (4)

Background G protein-coupled receptor kinase 4 (GRK4) is considered a central regulator of blood pressure through phosphorylation of renal dopaminergi......

Thiazides Attenuate Insulin Secretion Through Inhibition of Mitochondrial Carbonic Anhydrase 5b in β-Islet Cells in Mice

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2023; 34 (7)

Background Thiazide diuretics are associated with glucose intolerance and new-onset diabetes mellitus. Previous studies demonstrated that thiazides at......

Erythrocyte ENT1-AMPD3 Axis is an Essential Purinergic Hypoxia Sensor and Energy Regulator Combating CKD in a Mouse Model

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2023; 34 (10)

Background Hypoxia drives kidney damage and progression of CKD. Although erythrocytes respond rapidly to hypoxia, their role and the specific molecule......

Initial Management and Potential Opportunities to Deprescribe Dialysis among Patients with AKI-D Patients after Hospital Discharge

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2023; 34 (12)

Significance StatementDialysis-requiring AKI (AKI-D) now accounts for more than 15% of outpatient hemodialysis initiations; over 30% of these patients......

ADAMTS7-Mediated Complement Factor H Degradation Potentiates Complement Activation to Contributing to Renal Injuries

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2023; 34 (2)

Background The dysfunction of complement factor H (CFH), the main soluble complement negative regulator, potentiates various complement-induced renal ......

Cardioprotective Effect of Acute Intradialytic Exercise: A Comprehensive Speckle-Tracking Echocardiography Analysis

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2023; 34 (8)

Background Hemodialysis (HD) induces left ventricular (LV) transient myocardial dysfunction. A complex interplay between linear deformations and torsi......

Genetic Variants of the COL4A3, COL4A4, and COL4A5 Genes Contribute to Thinned Glomerular Basement Membrane Lesions in Sporadic IgA Nephropathy Patients

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2023; 34 (1)

Background Thinned glomerular basement membrane (tGBM) lesions are not uncommon in IgA nephropathy (IgAN). Type IV collagen-built of alpha 3, alpha 4,......

Tubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery

期刊: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2023; 34 (3)

Background Late diagnosis is a hurdle for treatment of AKI, but targeting AKI-CKD transition may improve outcomes. High mobility group box-1 (HMGB1) i......

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