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The role of anlotinib-mediated EGFR blockade in a positive feedback loop of CXCL11-EGF-EGFR signalling in anaplastic thyroid cancer angiogenesis

期刊: BRITISH JOURNAL OF CANCER, 2021; 125 (3)

Background Hypoxia-induced angiogenesis functions importantly in anaplastic thyroid cancer (ATC) progression. However, the therapeutic potential of br......

Anlotinib vs placebo as third- or further-line treatment for patients with small cell lung cancer: a randomised, double-blind, placebo-controlled Phase 2 study

期刊: BRITISH JOURNAL OF CANCER, 2021; 125 (3)

Background This study aimed to evaluate the efficacy and safety of anlotinib as a third-line and subsequent treatment for patients with small cell lun......

Towards the understanding of the genetics of somatic mutations

期刊: BRITISH JOURNAL OF CANCER, 2021; 125 (5)

A recent study from Sun et al. reveals a polygenic architecture for pan-cancer tumour mutational burden (TMB) and shows the identification of genes un......

Promises and challenges of adoptive T-cell therapies for solid tumours

期刊: BRITISH JOURNAL OF CANCER, 2021; 124 (11)

Cancer is a leading cause of death worldwide and, despite new targeted therapies and immunotherapies, many patients with advanced-stage- or high-risk ......

S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer

期刊: BRITISH JOURNAL OF CANCER, 2021; 125 (5)

Background SLC2A5 is a high-affinity fructose transporter, which is frequently upregulated in multiple human malignant tumours. However, the function ......

A nomogram prognostic index for risk-stratification in diffuse large B-cell lymphoma in the rituximab era: a multi-institutional cohort study

期刊: BRITISH JOURNAL OF CANCER, 2021; 125 (3)

Background We aimed to establish a predictive prognostic risk-stratification model for diffuse large B-cell lymphoma (DLBCL) in the rituximab era. Met......

Metabolic expression profiling stratifies diffuse lower-grade glioma into three distinct tumour subtypes

期刊: BRITISH JOURNAL OF CANCER, 2021; 125 (2)

Background Lower-grade gliomas (LGGs) show highly metabolic heterogeneity and adaptability. To develop effective therapeutic strategies targeting meta......

Multicentre study of microwave ablation for pulmonary oligorecurrence after radical resection of non-small-cell lung cancer

期刊: BRITISH JOURNAL OF CANCER, 2021; 125 (5)

Background Microwave ablation (MWA) is an effective minimally invasive technique for lung tumours. We aim to evaluate its role for pulmonary oligorecu......

Identification of diagnostic markers and lipid dysregulation in oesophageal squamous cell carcinoma through lipidomic analysis and machine learning

期刊: BRITISH JOURNAL OF CANCER, 2021; 125 (3)

Background Oesophageal cancer (EC) ranks high in both morbidity and mortality. A non-invasive and high-sensitivity diagnostic approach is necessary to......

Predicting the clinical outcome of oral potentially malignant disorders using transcriptomic-based molecular pathology

期刊: BRITISH JOURNAL OF CANCER, 2021; 125 (3)

Background This study was undertaken to develop and validate a gene expression signature that characterises oral potentially malignant disorders (OPMD......

alpha-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study

期刊: BRITISH JOURNAL OF CANCER, 2021; 124 (12)

Background Pathologic diagnosis of hepatocellular carcinoma (HCC) can be challenging in differentiating from benign and non-hepatocytic malignancy les......

Porphyromonas gingivalis infection exacerbates oesophageal cancer and promotes resistance to neoadjuvant chemotherapy

期刊: BRITISH JOURNAL OF CANCER, 2021; 125 (3)

Background The effect of Porphyromonas gingivalis (Pg) infection on oesophageal squamous cell carcinoma (ESCC) prognosis, chemotherapeutic efficacy, a......

CD8(+) T cells inhibit metastasis and CXCL4 regulates its function

期刊: BRITISH JOURNAL OF CANCER, 2021; 125 (2)

BACKGROUND: The mechanism by which immune cells regulate metastasis is unclear. Understanding the role of immune cells in metastasis will guide the de......

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