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Chemical Composition and Biological Activities of Endophytic Fungus Talaromyces Wortmannii LGT-4, Cultured in CYM Medium

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2020; 19 (2)

In the present study, nine compounds (1-9) were isolated from Talaromyces wortmannii LGT-4 (an endophytic fungus from Tripterygium wilfordi) which was......

Multivesicular Liposome (Depofoam) in Human Diseases

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2020; 19 (2)

Drug development is a key point in the research of new therapeutic treatments for increasing maximum drug loading and prolonged drug effect. Encapsula......

Isolation, Purification and Antioxidant Activity of The Polysaccharides from Chinese Truffle Tuber sinense

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2020; 19 (1)

The content of polysaccharides in Tuber sinense was investigated by isolation and purification, followed with the further antioxidant studies in total......

Original Article A Randomized, Open, Single-Centre, Crossed Study of the Effect of Food on the Pharmacokinetics of One Oral Dose of Alflutinib Mesylate Tablets (AST2818) in Healthy Male Subjects

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2020; 19 (3)

The aim of the study was to study the PK of AST2818 tablets after one oral dose in healthy male subjects on an empty stomach and in a postprandial sta......

Enhanced Solubility and Bioavailabitity of Apigenin via Preparation of Solid Dispersions of Mesoporous Silica Nanoparticles

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2019; 18 (1)

In this study, a novel mesoporous silica nanoparticles drug carrier contributes to improving the solubility, dissolution, and the oral bioavailability......

JIF:1.18

How Much Vancomycin Dose Is Enough For The MRSA Infection in Pediatric Patients With Various Degrees of Renal Function?

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2019; 18 (2)

Today, an increase in vancomycin dose has been proposed to ensure efficacy. However, the risk of nephrotoxicity will increase with the dose. The aim o......

JIF:1.18

Fingerprint Analysis and Quantitative Determination of Fourteen Active Components in the Traditional Chinese Medicinal Preparation Feiyang changweiyan Capsule by HPLC-DAD-ESI-MS/MS

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2019; 18 (2)

FeiYangchangweiyan capsule (FY capsule), a traditional Chinese medicinal preparation consisting of three medicinal herbs, has been used to treat bacte......

JIF:1.18

Screening and Isolation of Natural Antioxidants from Acer Ginnala Max by TLC-MS/MS Guided Bioautographic Method

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2019; 18 (2)

A rapid and simple method has been developed for the screening and identification of natural antioxidants from the leaves of Acer ginnala Maxim (AG). ......

JIF:1.18

Anti-tumor Effect of Ginkgo biloba Exocarp Extracts on B16 Melanoma Bearing Mice Involving P I3K/Akt/HIF-1 alpha/VEGF Signaling Pathways

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2019; 18 (2)

The objective of this study is to investigate the anti-tumor effect of Ginkgo biloba exocarp extracts (GBEE) on B16 melanoma bearing mice and its rela......

JIF:1.18

Preparation of a Major Metabolite of Iguratimod and Simultaneous Assay of Iguratimod and Its Metabolite by HPLC in Rat Plasma

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2019; 18 (2)

Iguratimod is a new synthetic disease-modifying antirheumatic drug intended to treat patients with rheumatoid arthritis. A new method using recombinan......

JIF:1.18

Preparation of Ethyl Cellulose Microspheres for Sustained Release of Sodium Bicarbonate

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2019; 18 (2)

Sustained release of thermal-instable and water-soluble drugs with low molecule weight is a challenge. In this study, sodium bicarbonate was encapsula......

JIF:1.18

Improving Activity of Lycium Barbarum. Polysaccharide on Depressive Mice Induced by Reserpine

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2019; 18 (3)

Depressive disorder will be the second highest disease burden worldwide, which will impair life quality, reduce productivity, and increase disability ......

JIF:1.18

Natural Alpha-Glucosidase Inhibitors Rapid Fishing from Cyperus Rotundus Using Immobilized Enzyme Affinity Screening Combined with UHPLC-QTOF MS

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2019; 18 (3)

An efficient and rapid affinity-based screening method for directly fishing out natural alpha-glucosidase inhibitors from Cyperus rotundus extract by ......

JIF:1.18

A New Model to Describe the Single-dose Pharmacokinetics of Bevacizumab and Predict Its Multiple-Dose Pharmacokinetics in Beagle Dogs

期刊: IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH, 2019; 18 (3)

Complex pharmacokinetic (PK) properties including nonlinear elimination were encountered by some monoclonal antibodies (mAbs), and classic compartment......

JIF:1.18

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