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Plant adaptation to climate change

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (22)

Plants are vital to human health and well-being, as well as helping to protect the environment against the negative impacts of climate change. They ar......

The choreography of protein kinase PDK1 and its diverse substrate dance partners

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (19)

The protein kinase PDK1 phosphorylates at least 24 distinct substrates, all of which belong to the AGC protein kinase group. Some substrates, such as ......

Enzyme function and evolution through the lens of bioinformatics

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (22)

Enzymes have been shaped by evolution over billions of years to catalyse the chemical reactions that support life on earth. Dispersed in the literatur......

Root system growth and development responses to elevated CO2: underlying signalling mechanisms and role in improving plant CO2 capture and soil C storage

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (11)

Carbon storage in soils is one of the most promising strategies for mitigating greenhouse gas emissions and the associated climate change. In this con......

Photoaffinity labelling displacement assay using multiple recombinant protein domains

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (15)

The development and optimisation of a photoaffinity labelling (PAL) displacement assay is presented, where a highly efficient PAL probe was used to re......

Proteotoxic stresses stimulate dissociation of UBL4A from the tail-anchored protein recognition complex

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (19)

Inclusion body formation is associated with cytotoxicity in a number of neurodegenerative diseases. However, the molecular basis of the toxicity cause......

RhoGAP6 interacts with COPI to regulate protein transport

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (14)

RhoGAP6 is the most highly expressed GTPase-activating protein (GAP) in platelets specific for RhoA. Structurally RhoGAP6 contains a central catalytic......

CRISPR/Cas9-based edition of frataxin gene in Dictyostelium discoideum

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (19)

In this paper, we describe the development of a Dictyostelium discoideum strain deficient in frataxin protein (FXN). We investigated the conservation ......

MicroRNA, miR-501 regulate the V(D)J recombination in B cells

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (24)

The stringent regulation of RAGs (Recombination activating genes), the site-specific endonuclease responsible for V(D)J recombination, is important to......

Paradigms of receptor kinase signaling in plants

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (12)

Plant receptor kinases (RKs) function as key plasma-membrane localized receptors in the perception of molecular ligands regulating development and env......

Up-regulation of SLC7A11/xCT creates a vulnerability to selenocystine-induced cytotoxicity

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (24)

The SLC7A11/xCT cystine and glutamate antiporter has emerged as an attractive target for cancer therapy due to its selective overexpression in multipl......

Key allosteric and active site residues of SARS-CoV-2 3CLpro are promising drug targets

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (11)

The main protease of SARS-CoV-2, 3-chymotrypsin-like protease (3CLpro), is a prominent target for antiviral development due to its essential role in t......

Calcium signalling components underlying NPK homeostasis: potential avenues for exploration

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (13)

Plants require the major macronutrients, nitrogen (N), phosphorus (P) and potassium (K) for normal growth and development. Their deficiency in soil di......

Revisiting the roles of cAMP signalling in the progression of prostate cancer

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (20)

Prostate cancer is one of the most common cancers in men and one of the top causes of death in men worldwide. Development and function of both normal ......

Overexpression of ARM repeat/U-box containing E3 ligase, PUB2 positively regulates growth and oxidative stress response in Arabidopsis

期刊: BIOCHEMICAL JOURNAL, 2023; 480 (9)

Plant growth and development are governed by selective protein synthesis and degrad-ation. Ubiquitination mediated protein degradation is governed by ......

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