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Methylglyoxal-an advanced glycation end products (AGEs) precursor-Inhibits differentiation of human MSC-derived osteoblasts in vitro independently of receptor for AGEs (RAGE)

期刊: BONE, 2022; 164 ()

A major precursor of advanced glycation end-products (AGEs) -methylglyoxal (MG) -is a reactive carbonyl metabolite that originates from glycolytic pat......

JIF:4.047

Development and external validation of a 1-and 5-year fracture prediction tool based on electronic medical records data: The EPIC risk algorithm

期刊: BONE, 2022; 162 ()

Objectives: We aimed to develop and validate a fracture risk algorithm for the automatic identification of subjects at high risk of imminent and long-......

JIF:4.047

MiR-1 is a critical regulator of chondrocyte proliferation and hypertrophy by inhibiting Indian hedgehog pathway during postnatal endochondral ossification in miR-1 overexpression transgenic mice

期刊: BONE, 2022; 165 ()

Endochondral bone formation from the growth plate plays a critical role in vertebrate limb development and skeletal homeostasis. Although miR-1 is mai......

JIF:4.047

Meeting the challenges and clinical requirements for dental regeneration; the New Zealand experience

期刊: BONE, 2022; 154 ()

Disease and trauma leading to tooth loss and destruction of supporting bone is a significant oral handicap, which may be addressed through surgical th......

JIF:4.047

From hurdle to springboard: The macrophage as target in biomaterial-based bone regeneration strategies

期刊: BONE, 2022; 159 ()

The past decade has seen a growing appreciation for the role of the innate immune response in mediating repair and biomaterial directed tissue regener......

JIF:4.047

Large-scale osteocyte lacunar morphological analysis of transiliac bone in normal and osteoporotic premenopausal women

期刊: BONE, 2022; 160 ()

Bone's ability to adapt is governed by the network of embedded osteocytes, which inhabit individual pores called lacunae. The morphology of these lacu......

JIF:4.047

Mechanisms of bone resorption

期刊: BONE, 2022; 163 ()

Resorption of mineralized tissues like bone is accomplished by a unique cell type: the osteoclast. This multi -nucleated cell has the capacity to diss......

JIF:4.047

Osteoclast-poor osteopetrosis

期刊: BONE, 2022; 164 ()

Osteopetrosis (OPT) is a rare inherited bone disease characterized by a bone resorption defect, due to osteoclast malfunction (in osteoclast-rich, oc-......

JIF:4.047

Influence of loading conditions in finite element analysis assessed by HR-pQCT on ex vivo fracture prediction

期刊: BONE, 2022; 154 ()

Many fractures occur in individuals with normal areal Bone Mineral Density (aBMD) measured by Dual X-ray Absorptiometry (DXA). High Resolution periphe......

JIF:4.047

Finite element derived femoral strength is a better predictor of hip fracture risk than aBMD in the AGES Reykjavik study cohort

期刊: BONE, 2022; 154 ()

Hip fractures associated with a high economic burden, loss of independence, and a high rate of post-fracture mortality, are a major health concern for......

JIF:4.047

Impact of magnesium on bone health in older adults: A systematic review and meta-analysis

期刊: BONE, 2022; 154 ()

Background: Magnesium plays a key role in bone health and may, therefore, represent an interesting nutrient for the prevention of bone loss and osteop......

JIF:4.047

Modulating the systemic and local adaptive immune response after fracture improves bone regeneration during aging

期刊: BONE, 2022; 157 ()

Tissue injury leads to the well-orchestrated mobilization of systemic and local innate and adaptive immune cells. During aging, immune cell recruitmen......

JIF:4.047

Fibrous dysplasia animal models: A systematic review

期刊: BONE, 2022; 155 ()

Background: Fibrous dysplasia (FD) is a rare genetic bone disorder resulting in an overproduction of cAMP leading to a structurally unsound tissue, ca......

JIF:4.047

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