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DDAH2 suppresses RLR-MAVS-mediated innate antiviral immunity by stimulating nitric oxide-activated, Drp1-induced mitochondrial fission

期刊: SCIENCE SIGNALING, 2021; 14 (678)

The RIG-I-like receptor (RLR) signaling pathway is pivotal for innate immunity against invading viruses, and dysregulation of this molecular cascade h......

The PdeK-PdeR two-component system promotes unipolar localization of FimX and pilus extension in Xanthomonas oryzae pv. oryzicola

期刊: SCIENCE SIGNALING, 2021; 14 (700)

Bacterial type IV pili (T4P) contribute to virulence and can be rapidly extended and retracted to mediate twitching motility. T4P biogenesis, which is......

Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu(2)/mGlu(4) receptor heterodimers

期刊: SCIENCE SIGNALING, 2021; 14 (677)

Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors that regulate various aspects of central nervous system processing in normal......

Kynurenic acid may underlie sex-specific immune responses to COVID-19

期刊: SCIENCE SIGNALING, 2021; 14 (690)

Coronavirus disease 2019 (COVID-19) has poorer clinical outcomes in males than in females, and immune responses underlie these sex-related differences......

Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic beta-catenin degradation

期刊: SCIENCE SIGNALING, 2021; 14 (665)

Cranial neural crest cells (CNCCs) are a population of multipotent stem cells that give rise to craniofacial bone and cartilage during development. Bo......

Activin A promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice

期刊: SCIENCE SIGNALING, 2021; 14 (669)

Heterotopic ossification (HO) is a common, potentially debilitating pathology that is instigated by inflammation caused by tissue damage or other insu......

Control of ribosomal protein synthesis by the Microprocessor complex

期刊: SCIENCE SIGNALING, 2021; 14 (671)

Ribosome biogenesis in eukaryotes requires the coordinated production and assembly of 80 ribosomal proteins and four ribosomal RNAs (rRNAs), and its r......

IFN-kappa suppresses the replication of influenza A viruses through the IFNAR-MAPK-Fos-CHD6 axis

期刊: SCIENCE SIGNALING, 2020; 13 (626)

Type I interferons (IFNs) are the first line of defense against viral infection. Using a mouse model of influenza A virus infection, we found that IFN......

Local Ca2+ signals couple activation of TRPV1 and ANO1 sensory ion channels

期刊: SCIENCE SIGNALING, 2020; 13 (629)

ANO1 (TMEM16A) is a Ca2+-activated Cl- channel (CaCC) expressed in peripheral somatosensory neurons that are activated by painful (noxious) stimuli. T......

Myeloma cells shift osteoblastogenesis to adipogenesis by inhibiting the ubiquitin ligase MURF1 in mesenchymal stem cells

期刊: SCIENCE SIGNALING, 2020; 13 (633)

The suppression of bone formation is a hallmark of multiple myeloma. Myeloma cells inhibit osteoblastogenesis from mesenchymal stem cells (MSCs), whic......

Ubiquitination and functional modification of GluN2B subunit-containing NMDA receptors by Cbl-b in the spinal cord dorsal horn

期刊: SCIENCE SIGNALING, 2020; 13 (638)

N-methyl-D-aspartate (NMDA) glutamate receptors (NMDARs) containing GluN2B subunits are prevalent early after birth in most brain regions in rodents. ......

The ER chaperone calnexin controls mitochondrial positioning and respiration

期刊: SCIENCE SIGNALING, 2020; 13 (638)

Chaperones in the endoplasmic reticulum (ER) control the flux of Ca2+ ions into mitochondria, thereby increasing or decreasing the energetic output of......

Two glutamate- and pH-regulated Ca2+ channels are required for systemic wound signaling in Arabidopsis

期刊: SCIENCE SIGNALING, 2020; 13 (640)

Plants defend against herbivores and nematodes by rapidly sending signals from the wounded sites to the whole plant. We investigated how plants genera......

A dynamic mouse peptidome landscape reveals probiotic modulation of the gut-brain axis

期刊: SCIENCE SIGNALING, 2020; 13 (642)

Certain probiotics have beneficial effects on the function of the central nervous system through modulation of the gut-brain axis. Here, we describe a......

Structural insights into the signal transduction mechanism of the K+-sensing two-component system KdpDE

期刊: SCIENCE SIGNALING, 2020; 13 (643)

Two-component systems (TCSs), which consist of a histidine kinase (HK) sensor and a response regulator (RR), are important for bacteria to quickly sen......

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