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Risk of immune-related diarrhea with PD-1/PD-L1 inhibitors in different cancer types and treatment regimens

期刊: JOURNAL OF CANCER, 2020; 11 (1)

Objective: To compare the incidence and severity of diarrhea among different tumor types and treatment regimens, and also compared with CTLA-4 inhibit......

Consistency Analysis of Programmed Death-Ligand 1 Expression between Primary and Metastatic Non-Small Cell Lung Cancer: A Retrospective Study

期刊: JOURNAL OF CANCER, 2020; 11 (4)

Background: Programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) is considered as a predictive biomarker of anti-PD-1/PD......

Pyruvate dehydrogenase kinase 1 interferes with glucose metabolism reprogramming and mitochondrial quality control to aggravate stress damage in cancer

期刊: JOURNAL OF CANCER, 2020; 11 (4)

Pyruvate dehydrogenase kinase 1 (PDK1) is a key factor in the connection between glycolysis and the tricarboxylic acid cycle. Restoring the mitochondr......

LNC00673 suppresses proliferation and metastasis of pancreatic cancer via target miR-504/HNF1A

期刊: JOURNAL OF CANCER, 2020; 11 (4)

Pancreatic cancer is a highly invasive malignant tumor of the digestive system. To explore the mechanism of pancreatic cancer development, development......

The BRAF V600E mutation is a predictor of the effect of radioiodine therapy in papillary thyroid cancer

期刊: JOURNAL OF CANCER, 2020; 11 (4)

Objective: To investigate the correlation between the BRAF V600E gene mutation and clinicopathological features and thyroid function after iodine-131 ......

miR-125b-5p/STAT3 Pathway Regulated by mTORC1 Plays a Critical Role in Promoting Cell Proliferation and Tumor Growth

期刊: JOURNAL OF CANCER, 2020; 11 (4)

Aberrant activation of the mammalian target of rapamycin complex 1 (mTORC1) plays a critical role in tumorigenesis. However, the precise underlying me......

Comprehensive investigation of p53, p21, nm23, and VEGF expression in hepatitis B virus-related hepatocellular carcinoma overall survival after hepatectomy

期刊: JOURNAL OF CANCER, 2020; 11 (4)

Objective: The goal of our current study is to assess the immunohistochemical of p53, p21, nm23, and VEGF expression in hepatitis B virus (HBV)-relate......

DNA sensors, crucial receptors to resist pathogens, are deregulated in colorectal cancer and associated with initiation and progression of the disease

期刊: JOURNAL OF CANCER, 2020; 11 (4)

Background: DNA sensors are innate immune receptors that detect intracellular endogenous or exogenous DNA. They are critical to trigger immune respons......

An Exon Signature to Estimate the Tumor Mutational Burden of Right-sided Colon Cancer Patients

期刊: JOURNAL OF CANCER, 2020; 11 (4)

The clinical applicability of the whole-exome sequencing (WES) in estimating tumor mutational burden (TMB) is currently limited by high cost, time-con......

Interaction between fasting blood glucose and tumor embolus in predicting the postoperative prognosis of 4330 Chinese patients with gastrointestinal tract cancer

期刊: JOURNAL OF CANCER, 2020; 11 (4)

Objectives: We aimed to investigate the interaction between fasting blood glucose and tumor embolus, and the potential mediation effect of fasting blo......

MiR-129-5p sensitization of lung cancer cells to etoposide-induced apoptosis by reducing YWHAB

期刊: JOURNAL OF CANCER, 2020; 11 (4)

Background: Lung cancer is the most common cause of death from cancer worldwide and recent studies have revealed that microRNAs play critical roles to......

The Antipsychotic Agent Sertindole Exhibited Antiproliferative Activities by Inhibiting the STAT3 Signaling Pathway in Human Gastric Cancer Cells

期刊: JOURNAL OF CANCER, 2020; 11 (4)

Gastric cancer (GC) is the third leading cause of cancer-related death. Although the therapeutic approaches have improved, the 5-year survival rate of......

STAT3 signaling in ovarian cancer: a potential therapeutic target

期刊: JOURNAL OF CANCER, 2020; 11 (4)

Accumulating evidence has shown that Signal Transducer and Activator of Transcription 3 (STAT3) is thought to be a promising target for cancer therapy......

Critical role and its underlying molecular events of the plasminogen receptor, S100A10 in malignant tumor and non-tumor diseases

期刊: JOURNAL OF CANCER, 2020; 11 (4)

S100A10 is a small molecular weight protein expressed in the cytoplasm of many cells and one of the members of the S100 protein family that binds calc......

FGF14 Functions as a Tumor Suppressor through Inhibiting PI3K/AKT/mTOR Pathway in Colorectal Cancer

期刊: JOURNAL OF CANCER, 2020; 11 (4)

We identified that Fibroblast Growth Factor 14 (FGF14) was preferentially methylated in colorectal cancer (CRC). In this study, we aimed to investigat......

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