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LcrQ Coordinates with the YopD-LcrH Complex To Repress IcrF Expression and Control Type III Secretion by Yersinia pseudotuberculosis

期刊: MBIO, 2021; 12 (3)

Human-pathogenic Yersinia species employ a plasmid-encoded type III secretion system (T3SS) to negate immune cell function during infection. A critica......

Microbial Functional Responses Explain Alpine Soil Carbon Fluxes under Future Climate Scenarios

期刊: MBIO, 2021; 12 (1)

Soil microorganisms are sensitive to temperature in cold ecosystems, but it remains unclear how microbial responses are modulated by other important c......

Dynamic Dissection of the Endocytosis of Porcine Epidemic Diarrhea Coronavirus Cooperatively Mediated by Clathrin and Caveolae as Visualized by Single-Virus Tracking

期刊: MBIO, 2021; 12 (2)

Coronaviruses (CoVs) have caused severe diseases in humans and animals. Endocytic pathways, such as clathrin-mediated endocytosis (CME) and caveolae-m......

A Bacterial Toxin Perturbs Intracellular Amino Acid Balance To Induce Persistence

期刊: MBIO, 2021; 12 (1)

Bacterial cells utilize toxin-antitoxin systems to inhibit self-reproduction, while maintaining viability, when faced with environmental challenges. T......

Atomic Structure of the Trichomonas vaginalis Double-Stranded RNA Virus 2

期刊: MBIO, 2021; 12 (2)

Trichomonas vaginalis, the causative pathogen for the most common nonviral sexually transmitted infection worldwide, is itself frequently infected wit......

Screening of Chemical Libraries for New Antifungal Drugs against Aspergillus fumigatus Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine

期刊: MBIO, 2021; 12 (4)

Aspergillus fumigatus is an important fungal pathogen and the main etiological agent of aspergillosis, a disease characterized by a noninvasive proces......

Evaluation of Microbe-Driven Soil Organic Matter Quantity and Quality by Thermodynamic Theory

期刊: MBIO, 2021; 12 (1)

Microbial communities, coupled with substrate quality and availability, regulate the stock (formation versus mineralization) of soil organic matter (S......

Cyclic di-AMP Oversight of Counter-Ion Osmolyte Pools Impacts Intrinsic Cefuroxime Resistance in Lactococcus lactis

期刊: MBIO, 2021; 12 (2)

The broadly conserved cyclic di-AMP (c-di-AMP) is a conditionally essential bacterial second messenger. The pool of c-di-AMP is fine-tuned through dia......

Species-Specific Deamidation of RIG-I Reveals Collaborative Action between Viral and Cellular Deamidases in HSV-1 Lytic Replication

期刊: MBIO, 2021; 12 (2)

Retinoic acid-inducible gene I (RIG-I) is a sensor that recognizes cytosolic double-stranded RNA derived from microbes to induce host immune response.......

Compartmentalization of Melanin Biosynthetic Enzymes Contributes to Self-Defense against Intermediate Compound Scytalone in Botrytis cinerea

期刊: MBIO, 2021; 12 (2)

In filamentous fungi, 1,8-dihydroxynaphthalene (DHN) melanin is a major component of the extracellular matrix, endowing fungi with environmental toler......

Intra-Ramanome Correlation Analysis Unveils Metabolite Conversion Network from an Isogenic Population of Cells

期刊: MBIO, 2021; 12 (4)

To reveal the dynamic features of cellular systems, such as the correlation among phenotypes, a time or condition series set of samples is typically r......

Direct Observation of Electrically Conductive Pili Emanating from Geobacter sulfurreducens

期刊: MBIO, 2021; 12 (4)

Geobacter sulfurreducens is a model microbe for elucidating the mechanisms for extracellular electron transfer in several biogeochemical cycles, bioel......

Progesterone-Mediated Enhancement of Hepatitis E Virus Replication in Human Liver Cells

期刊: MBIO, 2021; 12 (3)

Progesterone is crucial for the maintenance of pregnancy. During pregnancy hepatitis E virus (HEV) infection is associated with increased fulminant he......

Host Species and Geography Differentiate Honeybee Gut Bacterial Communities by Changing the Relative Contribution of Community Assembly Processes

期刊: MBIO, 2021; 12 (3)

Honeybee gut microbiota modulates the health and fitness of honeybees, the ecologically and economically important pollinators and honey producers. Ho......

Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication

期刊: MBIO, 2021; 12 (4)

The coronavirus disease 2019 pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is an ongoing global public crisis. Altho......

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