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Inhibition of monoamine oxidase B reduces atherosclerosis and fatty liver in mice

期刊: CLINICAL SCIENCE, 2023; 137 (1)

Oxidative stress is vital for pathophysiology of atherosclerosis and non-alcoholic fatty liver disease (NAFLD). Monoamine oxidase (MAO) is an importan......

Ferredoxin 1 regulates granulosa cell apoptosis and autophagy in polycystic ovary syndrome

期刊: CLINICAL SCIENCE, 2023; 137 (6)

Polycystic ovary syndrome (PCOS), a common reproductive endocrine disorder in women of reproductive age, causes anovulatory infertility. Increased apo......

The biodistribution of placental and fetal extracellular vesicles during pregnancy following placentation

期刊: CLINICAL SCIENCE, 2023; 137 (5)

Human pregnancy is a highly orchestrated process requiring extensive cross-talk between the mother and the fetus. Extracellular vesicles released by t......

TNF/iNOS/NO pathway mediates host susceptibility to endothelial-dependent circulatory failure and death induced by betacoronavirus infection

期刊: CLINICAL SCIENCE, 2023; 137 (7)

Poor disease outcomes and lethality are directly related to endothelial dysfunction in beta-coronavirus infections. Here, we investigated the mechanis......

DsbA-L alleviates tubular injury in diabetic nephropathy by activating mitophagy through maintenance of MAM integrity

期刊: CLINICAL SCIENCE, 2023; 137 (12)

Mitochondria-associated endoplasmic reticulum membranes (MAMs) regulate ATG14- and Beclin1-mediated mitophagy and play key roles in the development of......

The O-GlcNAc dichotomy: when does adaptation become pathological?

期刊: CLINICAL SCIENCE, 2023; 137 (22)

O-Linked attachment of beta-N-acetylglucosamine (O-GlcNAc) on serine and threonine residues of nuclear, cytoplasmic, and mitochondrial proteins is a h......

Increased methylglyoxal formation in plasma and tissues during a glucose tolerance test is derived from exogenous glucose

期刊: CLINICAL SCIENCE, 2023; 137 (8)

The dicarbonyl compound methylglyoxal (MGO) is a major precursor in the formation of advanced glycation endproducts (AGEs). MGO and AGEs are increased......

Systematic online living evidence summaries : emerging tools to accelerate evidence synthesis

期刊: CLINICAL SCIENCE, 2023; 137 (10)

Systematic reviews and meta-analysis are the cornerstones of evidence-based deci-sion making and priority setting. However, traditional systematic rev......

ANGPTL8 deletion attenuates abdominal aortic aneurysm formation in ApoE-/- mice

期刊: CLINICAL SCIENCE, 2023; 137 (12)

Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism, glucose metabolism, inflammation, and cell proliferation and migratio......

Decoding the role of leptin and adiponectin in obesity-related gastrointestinal cancer

期刊: CLINICAL SCIENCE, 2023; 137 (15)

The increasing prevalence of obesity brings forward its importance as a risk factor for cancer development, particularly in the gastrointestinal tract......

Overexpression of notch signaling in renin cells leads to a polycystic kidney phenotype

期刊: CLINICAL SCIENCE, 2023; 137 (1)

Polycystic kidney disease (PKD) is an inherited disorder that results in large kidneys, numerous fluid-filled cysts, and ultimately end-stage kidney d......

Hormonal regulation of metabolism-recent lessons learned from insulin and estrogen

期刊: CLINICAL SCIENCE, 2023; 137 (6)

Hormonal signaling plays key roles in tissue and metabolic homeostasis. Accumulated evidence has revealed a great deal of insulin and estrogen signali......

Akt2 deficiency alleviates oxidative stress in the heart and liver via up-regulating SIRT6 during high-fat diet-induced obesity

期刊: CLINICAL SCIENCE, 2023; 137 (10)

The present study aims to investigate the role of AKT2 in the pathogenesis of hepatic and cardiac lipotoxicity induced by lipid overload-induced obesi......

Targeting TLR4/3 using chlorogenic acid ameliorates LPS plus POLY I:C-induced acute respiratory distress syndrome via alleviating oxidative stress-mediated NLRP3/NF-κB axis

期刊: CLINICAL SCIENCE, 2023; 137 (10)

Acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) is a life-threatening condition caused due to significant pulmonary and systemic......

Restoration of the gut barrier integrity and restructuring of the gut microbiome in aging by angiotensin-(1-7)

期刊: CLINICAL SCIENCE, 2023; 137 (11)

Compromised barrier function of colon epithelium with aging is largely due to gut microbial dysbiosis. Recent studies implicate an important role for ......

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