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Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout/mutated mice

期刊: HUMAN REPRODUCTION UPDATE, 2021; 27 (1)

BACKGROUND Infertility is a major issue in human reproductive health, affecting an estimated 15% of couples worldwide. Infertility can result from dis......

Adjuvant treatment strategies in ovarian stimulation for poor responders undergoing IVF: a systematic review and network meta-analysis

期刊: HUMAN REPRODUCTION UPDATE, 2020; 26 (2)

BACKGROUND: Despite great advances in assisted reproductive technology, poor ovarian response (POR) is still considered as one of the most challenging......

Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology

期刊: HUMAN REPRODUCTION UPDATE, 2020; 26 (3)

BACKGROUND: Endometriosis is a benign gynaecological disease. Thus, it came as a complete surprise when it was reported recently that the majority of ......

Diagnosing adenomyosis: an integrated clinical and imaging approach

期刊: HUMAN REPRODUCTION UPDATE, 2020; 26 (3)

BACKGROUND: Adenomyosis is a benign uterine disorder where endometrial glands and stroma are pathologically demonstrated within the uterine myometrium......

Studying human reproductive biology through single-cell analysis and in vitro differentiation of stem cells into germ cell-like cells

期刊: HUMAN REPRODUCTION UPDATE, 2020; 26 (5)

BACKGROUND Understanding the molecular and cellular mechanisms of human reproductive development has been limited by the scarcity of human samples and......

Neurotrophins and glial cell line-derived neurotrophic factor in the ovary: physiological and pathophysiological implications

期刊: HUMAN REPRODUCTION UPDATE, 2019; 25 (2)

BACKGROUND Neurotrophins [nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4)] and g......

JIF:12.88

Effect of levothyroxine supplementation on pregnancy loss and preterm birth in women with subclinical hypothyroidism and thyroid autoimmunity: a systematic review and meta-analysis

期刊: HUMAN REPRODUCTION UPDATE, 2019; 25 (3)

BACKGROUND Subclinical hypothyroidism (SCH) and thyroid autoimmunity (TAI) are associated with adverse pregnancy outcomes such as pregnancy loss and p......

JIF:12.88

Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation

期刊: HUMAN REPRODUCTION UPDATE, 2019; 25 (3)

BACKGROUND Initially identified as suppressors of metastasis in various types of cancer, kisspeptins are a family of neuropeptides that are key regula......

JIF:12.88

Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis?

期刊: HUMAN REPRODUCTION UPDATE, 2018; 24 (5)

BACKGROUND: The drug research and development (R&D) for endometriosis/adenomyosis has been painfully slow. Most completed clinical trials on endom......

JIF:12.88

Reproductive factors, menopausal hormone therapies and primary liver cancer risk: a systematic review and dose-response meta-analysis of observational studies

期刊: HUMAN REPRODUCTION UPDATE, 2017; 23 (1)

BACKGROUND: A striking gender disparity in the incidence and outcome of primary liver cancer (PLC) has been well recognized. Mounting evidence from ba......

JIF:11.85

Oocyte-somatic cell interactions in the human ovary-novel role of bone morphogenetic proteins and growth differentiation factors

期刊: HUMAN REPRODUCTION UPDATE, 2017; 23 (1)

BACKGROUND: Initially identified for their capability to induce heterotopic bone formation, bone morphogenetic proteins (BMPs) are multifunctional gro......

JIF:11.85

Assessment of the uterus with three-dimensional ultrasound in women undergoing ART

期刊: HUMAN REPRODUCTION UPDATE, 2017; 23 (2)

BACKGROUND: A detailed assessment of the uterus forms a pivotal part of the ART treatment process. The emergence of threedimensional ultrasound (3D US......

JIF:11.85

Administration of growth hormone improves endometrial function in women undergoing in vitro fertilization: a systematic review and meta-analysis

期刊: HUMAN REPRODUCTION UPDATE, 2022; 28 (6)

BACKGROUND The positive effects of growth hormone (GH) on IVF are often attributed to improvements in oocyte and embryo quality. While emerging eviden......

JIF:12.527

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