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Single-cell immune profiling reveals distinct immune response in asymptomatic COVID-19 patients

期刊: SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021; 6 (1)

While some individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) present mild-to-severe disease, many SARS-CoV-2-infect......

Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc

期刊: SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021; 6 (1)

Actin filament associated protein 1 antisense RNA 1 (named AFAP1-AS1) is a long non-coding RNA and overexpressed in many cancers. This study aimed to ......

Ketogenic diet alleviates colitis by reduction of colonic group 3 innate lymphoid cells through altering gut microbiome

期刊: SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021; 6 (1)

Accumulating evidence suggests that ketogenic diets (KDs) mediate the rise of circulating ketone bodies and exert a potential anti-inflammatory effect......

Gender associates with both susceptibility to infection and pathogenesis of SARS-CoV-2 in Syrian hamster

期刊: SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021; 6 (1)

Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung illness. To experimentally demonstrate the epidemiol......

Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection

期刊: SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021; 6 (1)

Bitter receptors function primarily in sensing taste, but may also have other functions, such as detecting pathogenic organisms due to their agile res......

Inflammation, epigenetics, and metabolism converge to cell senescence and ageing: the regulation and intervention

期刊: SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021; 6 (1)

Remarkable progress in ageing research has been achieved over the past decades. General perceptions and experimental evidence pinpoint that the declin......

Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome

期刊: SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021; 6 (1)

Severe fever with thrombocytopenia syndrome (SFTS) virus (SFTSV) is an emerging tick-borne virus with high fatality and an expanding endemic. Currentl......

FLT3 tyrosine kinase inhibitors synergize with BCL-2 inhibition to eliminate FLT3/ITD acute leukemia cells through BIM activation

期刊: SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021; 6 (1)

Tyrosine kinase inhibitors (TKIs) targeting FLT3 have shown activity but when used alone have achieved limited success in clinical trials, suggesting ......

Cyst(e)ine in nutrition formulation promotes colon cancer growth and chemoresistance by activating mTORC1 and scavenging ROS

期刊: SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021; 6 (1)

Weight loss and cachexia are common problems in colorectal cancer patients; thus, parenteral and enteral nutrition support play important roles in can......

Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma

期刊: SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021; 6 (1)

Glioblastoma (GBM), one of the most common primary intracranial malignant tumours, is very difficult to be completely excised by surgery due to its ir......

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