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Pentraxin 3 regulates tyrosine kinase inhibitor-associated cardiomyocyte contraction and mitochondrial dysfunction via ERK/JNK signalling pathways

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 157 ()

Background: Hepatocellular carcinoma (HCC) patients suffer varying degrees of heart dysfunction after tyrosine kinase inhibitor (TKI) treatment. Inter......

Zuogui-Jiangtang-Qinggan-Fang alleviates high-fat diet-induced type 2 diabetes mellitus with non-alcoholic fatty liver disease by modulating gut microbiome-metabolites-short chain fatty acid composition

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 157 ()

Non-alcoholic fatty liver disease (NAFLD) pathogenesis is affected by dysbiosis of the gut microbiome and the metabolites it generates. Therefore, res......

The biomedical potential of tardigrade proteins: A review

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 158 ()

Tardigrades are ubiquitous microinvertebrates exhibiting extreme tolerance to various environmental stressors like low and high temperatures, lack of ......

Attenuated WNV-poly(A) exerts a broad-spectrum oncolytic effect by selective virus replication and CD8+T cell-dependent immune response

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 158 ()

As an emerging tumor therapy, ideal oncolytic viruses preferentially replicate in malignant cells, reverse the immunosuppressive tumor microenvironmen......

Lathyrol promotes ER stress-induced apoptosis and proliferation inhibition in lung cancer cells by targeting SERCA2

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 158 ()

Lathyrol is a natural product isolated from the traditional Chinese medicine Semen Euphorbiae with unknown anti-tumor effects. We found that lathyrol ......

Experimental and approved treatments for skin photosensitivity in individuals with erythropoietic protoporphyria or X-linked protoporphyria: A systematic review

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 158 ()

Erythropoietic protoporphyria (EPP) and X-linked protoporphyria (XLP) are characterized by skin photosensitivity caused by accumulation of protoporphy......

Endothelin type A receptor blockade increases renoprotection in congestive heart failure combined with chronic kidney disease: Studies in 5/6 nephrectomized rats with aorto-caval fistula

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 158 ()

Background: Association of congestive heart failure (CHF) and chronic kidney disease (CKD) worsens the patient's prognosis and results in poor surviva......

Innovative challenge for the inhibition of hepatocellular carcinoma progression by combined targeting of HSP90 and STAT3/HIF-1α signaling

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 158 ()

Hepatocellular carcinoma (HCC) is the third foremost cause of cancer-related deaths. HCC has a very bad prognosis because it is asymptomatic in the ea......

Bioinformatics and computational analyses of kidney stone modulatory proteins lead to solid experimental evidence and therapeutic potential

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 159 ()

In recent biomedical research, bioinformatics and computational analyses have played essential roles for examining experimental findings and database ......

Mitochondrial disorder and treatment of ischemic cardiomyopathy: Potential and advantages of Chinese herbal medicine

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 159 ()

Mitochondrial dysfunction is the main cause of damage to the pathological mechanism of ischemic cardiomy-opathy. In addition, mitochondrial dysfunctio......

Inter and intracellular mitochondrial transfer: Future of mitochondrial transplant therapy in Parkinson?s disease

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 159 ()

Parkinson's disease (PD) is marked by the gradual degeneration of dopaminergic neurons and the intracellular build-up of Lewy bodies rich in alpha-syn......

Computer-aided drug design for the pain-like protease (PLpro) inhibitors against SARS-CoV-2

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 159 ()

A new coronavirus, known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is a highly contagious virus and has caused a massive worldw......

Brain targeted borneol-baicalin liposome improves blood-brain barrier integrity after cerebral ischemia-reperfusion injury via inhibiting HIF-1α/VEGF/eNOS/NO signal pathway

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 160 ()

Baicalin (BA) is widely used in the treatment of cerebral ischemia-reperfusion injury (CIRI). The key to treating encephalopathy is to increase the am......

XPO1 intensifies sorafenib resistance by stabilizing acetylation of NPM1 and enhancing epithelial-mesenchymal transition in hepatocellular carcinoma

期刊: BIOMEDICINE & PHARMACOTHERAPY, 2023; 160 ()

Emerging studies have suggested that exportin-1 (XPO1) plays a pivotal role in hepatocellular carcinoma (HCC). However, the underlying mechanism of XP......

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