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A large- scale genetic correlation scan between rheumatoid arthritis and human plasma protein

期刊: BONE & JOINT RESEARCH, 2022; 11 (2)

Aims The aim of this study was to explore the genetic correlation and causal relationship between blood plasma proteins and rheumatoid arthritis (RA).......

Complete abrogation of key osteoclast markers with a membrane- anchored tissue inhibitor of metalloproteinase

期刊: BONE & JOINT RESEARCH, 2022; 11 (11)

Aims Tissue inhibitors of metalloproteinases (TIMPs) are the endogenous inhibitors of the zinc -dependent matrix metalloproteinases (MMP) and A disint......

GDF11 inhibits abnormal adipogenesis of condylar chondrocytes in temporomandibular joint osteoarthritis

期刊: BONE & JOINT RESEARCH, 2022; 11 (7)

Aims Abnormal lipid metabolism is involved in the development of osteoarthritis (OA). Growth differentiation factor 11 (GDF11) is crucial in inhibitin......

Osteocyte- specific dentin matrix protein 1

期刊: BONE & JOINT RESEARCH, 2022; 11 (7)

Aims There is an increasing concern of osteoporotic fractures in the ageing population. Low -magnitude high-frequency vibration (LMHFV) was shown to s......

Immunomodulatory role of T helper cells in rheumatoid arthritis A COMPREHENSIVE RESEARCH REVIEW

期刊: BONE & JOINT RESEARCH, 2022; 11 (7)

Rheumatoid arthritis (RA) is an autoimmune disease that involves T and B cells and their reciprocal immune interactions with proinflammatory cytokines......

Modelling osteoarthritis in mice via surgical destabilization of the medial meniscus with or without a stereomicroscope

期刊: BONE & JOINT RESEARCH, 2022; 11 (8)

Aims To evaluate inducing osteoarthritis (OA) by surgical destabilization of the medial meniscus (DMM) in mice with and without a stereomicroscope. Me......

Fracture-related infection in osteoporotic bone causes more severe infection and further delays healing

期刊: BONE & JOINT RESEARCH, 2022; 11 (2)

Aims With the ageing population, fragility fractures have become one of the most common conditions. The objective of this study was to investigate whe......

Exercise modifies the disease- relevant gut microbial shifts in post- traumatic osteoarthritis rats

期刊: BONE & JOINT RESEARCH, 2022; 11 (4)

Aims Post-traumatic osteoarthritis (PTOA) is a subset of osteoarthritis (OA). The gut microbiome is shown to be involved in OA. However, the effect of......

Platelets mediate trained immunity against bone and joint infections in a mouse model

期刊: BONE & JOINT RESEARCH, 2022; 11 (2)

Aims Trained immunity confers non-specific protection against various types of infectious diseases, including bone and joint infection. Platelets are ......

Tibial cortex transverse transport accelerates wound healing via enhanced angiogenesis and immunomodulation

期刊: BONE & JOINT RESEARCH, 2022; 11 (4)

Aims Treatment for delayed wound healing resulting from peripheral vascular diseases and diabetic foot ulcers remains a challenge. A novel surgical te......

The role of Staphylococcus aureus small colony variants in intraosseous invasion and colonization in periprosthetic joint infection

期刊: BONE & JOINT RESEARCH, 2022; 11 (12)

Medical Aims This study aimed to explore the role of small colony variants (SCVs) of Staphylococcus aureus in intraosseous invasion and colonization i......

Effect of secretory leucocyte protease inhibitor on early tendon-to-bone healing after anterior cruciate ligament reconstruction in a rat model

期刊: BONE & JOINT RESEARCH, 2022; 11 (7)

Aims To verify whether secretory leucocyte protease inhibitor (SLPI) can promote early tendon-to-bone healing after anterior cruciate ligament (ACL) r......

CircSCAPER contributes to IL-1 beta-induced osteoarthritis in vitro via miR-140-3p/EZH2 axis

期刊: BONE & JOINT RESEARCH, 2022; 11 (2)

Aims Circular RNA (circRNA) S-phase cyclin A-associated protein in the endoplasmic reticulum (ER) (circSCAPER, ID: hsa_circ_0104595) has been found to......

Accumulation of advanced oxidation protein products contributes to age-related impairment of gap junction intercellular communication in osteocytes of male mice

期刊: BONE & JOINT RESEARCH, 2022; 11 (7)

Aims Gap junction intercellular communication (GJIC) in osteocytes is impaired by oxidative stress, which is associated with age-related bone loss. Ag......

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