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Development of a novel combined nomogram model integrating deep learning-pathomics, radiomics and immunoscore to predict postoperative outcome of colorectal cancer lung metastasis patients

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Limited previous studies focused on the death and progression risk stratification of colorectal cancer (CRC) lung metastasis patients. The aim of this......

JIF:10.743

Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Drug resistance represents a major obstacle in cancer management, and the mechanisms underlying stress adaptation of cancer cells in response to thera......

JIF:10.743

Super-enhancer hijacking LINC01977 promotes malignancy of early-stage lung adenocarcinoma addicted to the canonical TGF-beta/SMAD3 pathway

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Background: Lung adenocarcinoma (LUAD) is the leading cause of death worldwide. However, the roles of long noncoding RNAs (lncRNAs) hijacked by super-......

JIF:10.743

CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Background Circular RNAs (circRNAs) represent a novel type of regulatory RNA characterized by high evolutionary conservation and stability. CircRNAs a......

JIF:10.743

Altered pathways and targeted therapy in double hit lymphoma

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

High-grade B-cell lymphoma with translocations involving MYC and BCL2 or BCL6, usually referred to as double hit lymphoma (DHL), is an aggressive hema......

JIF:10.743

Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Disrupting the methylation of telomeric silencing 1-like (DOT1L)-mediated histone H3 lysine 79 has been implicated in MLL fusion-mediated leukemogenes......

JIF:10.743

Tumor organoids: applications in cancer modeling and potentials in precision medicine

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Cancer is a top-ranked life-threatening disease with intratumor heterogeneity. Tumor heterogeneity is associated with metastasis, relapse, and therapy......

JIF:10.743

How we treat NK/T-cell lymphomas

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Natural killer (NK)/T-cell lymphomas are aggressive malignancies with a predilection for Asian and South American populations. Epstein-Barr virus (EBV......

JIF:10.743

First-in-human phase I study of CLL-1 CAR-T cells in adults with relapsed/refractory acute myeloid leukemia

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Relapsed or refractory (R/R) acute myeloid leukemia (AML) has a poor prognosis. In this study, we evaluated chimeric antigen receptor (CAR) T cell the......

JIF:10.743

Therapeutic strategies for EGFR-mutated non-small cell lung cancer patients with osimertinib resistance

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are the preferential options for advanced non-small cell lung cancer (NSCLC) p......

JIF:10.743

Targeting extracellular matrix stiffness and mechanotransducers to improve cancer therapy

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Cancer microenvironment is critical for tumorigenesis and cancer progression. The extracellular matrix (ECM) interacts with tumor and stromal cells to......

JIF:10.743

Targeting regulated cell death (RCD) with small-molecule compounds in triple-negative breast cancer: a revisited perspective from molecular mechanisms to targeted therapies

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Triple-negative breast cancer (TNBC) is a subtype of human breast cancer with one of the worst prognoses, with no targeted therapeutic strategies curr......

JIF:10.743

Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Hypoxia, a common feature of the tumor microenvironment in various types of cancers, weakens cytotoxic T cell function and causes recruitment of regul......

JIF:10.743

Immune checkpoint modulators in cancer immunotherapy: recent advances and emerging concepts

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

The discovery of immune checkpoint inhibitors (ICIs) has now been universally acknowledged as a significant breakthrough in tumor therapy after the ta......

JIF:10.743

Targeting macrophages in hematological malignancies: recent advances and future directions

期刊: JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022; 15 (1)

Emerging evidence indicates that the detection and clearance of cancer cells via phagocytosis induced by innate immune checkpoints play significant ro......

JIF:10.743

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