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Combination Therapies Targeting ALK-aberrant Neuroblastoma in Preclinical Models

期刊: CLINICAL CANCER RESEARCH, 2023; 29 (7)

Purpose: ALK-activating mutations are identified in approxi-mately 10% of newly diagnosed neuroblastomas and ALK ampli-fications in a further 1%-2% of......

Comprehensive ctDNA Measurements Improve Prediction of Clinical Outcomes and Enable Dynamic Tracking of Disease Progression in Advanced Pancreatic Cancer

期刊: CLINICAL CANCER RESEARCH, 2023; 29 (7)

Purpose: Circulating tumor DNA (ctDNA) has emerged as a promising tumor-specific biomarker in pancreatic cancer, but current evidence of the clinical ......

Randomized Trial of Tepotinib Plus Gefitinib versus Chemotherapy in EGFR-Mutant NSCLC with EGFR Inhibitor Resistance Due to MET Amplification: INSIGHT Final Analysis

期刊: CLINICAL CANCER RESEARCH, 2023; 29 (10)

Purpose: The final analyses of the INSIGHT phase II study evaluating tepotinib (a selective MET inhibitor) plus gefitinib versus chemotherapy in patie......

Intratumoral CD16± Macrophages Are Associated with Clinical Outcomes of Patients with Metastatic Melanoma Treated with Combination Anti-PD-1 and Anti-CTLA-4 Therapy

期刊: CLINICAL CANCER RESEARCH, 2023; 29 (13)

Purpose: This study characterizes intratumoral macrophage populations within baseline melanoma biopsies from patients with advanced melanoma who recei......

Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer

期刊: CLINICAL CANCER RESEARCH, 2023; 29 (14)

Purpose: No evidence exists as to whether type 2 diabetes mellitus (T2DM) impairs clinical outcome from immune check -point inhibitors (ICI) in patien......

Functional Homologous Recombination Assay on FFPE Specimens of Advanced High-Grade Serous Ovarian Cancer Predicts Clinical Outcomes

期刊: CLINICAL CANCER RESEARCH, 2023; 29 (16)

Purpose:Deficiency in homologous recombination (HR) repair of DNA damage is characteristic of many high-grade serous ovarian cancers (HGSC). It is imp......

Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity

期刊: CLINICAL CANCER RESEARCH, 2023; 29 (6)

Tumor-associated inflammation (TAI) is a feature of essen-tially all cancers and can confer both tumor-promoting and-suppressive functions. Cancer-ass......

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