There are functional benefits to exercise in muscle, even when performed late in life, but the contributions of epigenetic factors to late-life exerci......
Mammalian oocyte quality reduces with age. We show that prior to the occurrence of significant aneuploidy (9M in mouse), heterochromatin histone marks......
Aged cardiomyocytes develop a mismatch between energy demand and supply, the severity of which determines the onset of heart failure, and become prone......
Substantial spine loss in striatal medium spiny neurons (MSNs) and abnormal behaviors are common features of Parkinson's disease (PD). The caudate put......
Accelerated aging is a hallmark of Down syndrome (DS), with adults experiencing early-onset Alzheimer's disease and premature aging of the skin, hair,......
Parkinson's disease (PD) is characterized by phosphorylation and aggregation of the protein alpha-Synuclein and ensuing neuronal death progressing fro......
Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This progressive pathology often has psychological and medical c......
There is growing interest in the use of metformin to extend lifespan and prevent the onset of age-related disorders in non-diabetic individuals. The i......
The molecular mechanisms underlying functional decline during normal brain aging are poorly understood. Here, we identified the actin-associated prote......
Oxidative stress plays a central role in age-related macular degeneration (AMD). Iron, a potent generator of hydroxyl radicals through the Fenton reac......
Dopamine (DA) signaling via G protein-coupled receptors is a multifunctional neurotransmitter and neuroendocrine-immune modulator. The DA nigrostriata......
Cellular senescence, which is a major cause of tissue dysfunction with aging and multiple other conditions, is known to be triggered by p16(Ink4a) or ......
Intestinal epithelial cells (IECs) serve as both a physical and an antimicrobial barrier against the microbiota, as well as a conduit for signaling be......
The effect of a ketogenic diet (KD) on middle aged female mice is poorly understood as most of this work have been conducted in young female mice or d......
