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microRNA-133a exerts tumor suppressive role in oral squamous cell carcinoma through the Notch signaling pathway via downregulation of CTBP2

期刊: CANCER GENE THERAPY, 2022; 29 (1)

microRNAs (miRNAs) have been revealed to participate in some oral cancers and are proved to be effective. In the present study, we tried to explore th......

JIF:4.883

Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1

期刊: CANCER GENE THERAPY, 2022; 29 (1)

Significantly high-expressed circFLNA has been found in various cancer cell lines, but not in lung cancer. Therefore, this study aimed to explore the ......

JIF:4.883

LncRNA MAFG-AS1 promotes the malignant phenotype of ovarian cancer by upregulating NFKB1-dependent IGF1

期刊: CANCER GENE THERAPY, 2022; 29 (3-4)

Long non-coding RNAs (lncRNAs) were recently recognized to vitally function in a variety of cancer cellular events, including epithelial-mesenchymal t......

JIF:4.883

CRHBP is degraded via autophagy and exerts anti-hepatocellular carcinoma effects by reducing cyclin B2 expression and dissociating cyclin B2-CDK1 complex

期刊: CANCER GENE THERAPY, 2022; 29 (8-9)

Autophagy is the predominant self-eating catabolic pathway activated in response to nutrient starvation and hypoxia within the microenvironment of var......

JIF:4.883

Nrf2 overexpression increases the resistance of acute myeloid leukemia to cytarabine by inhibiting replication factor C4

期刊: CANCER GENE THERAPY, 2022; 29 (11)

Drug resistance is a key factor in the treatment failure of acute myeloid leukemia (AML). Nuclear factor E2-related factor 2 (Nrf2) plays a crucial ro......

JIF:4.883

METTL3-mediated N6-methyladenosine modification of DUSP5 mRNA promotes gallbladder-cancer progression

期刊: CANCER GENE THERAPY, 2022; 29 (7)

N-6-methyladenosine (m(6)A) RNA methylation and its associated methyltransferase METTL3 play an important role in tumorigenesis of a series of tumors.......

JIF:4.883

Adeno-associated virus-delivered alpha synuclein inhibits bladder cancer growth via the p53/p21 signaling pathway

期刊: CANCER GENE THERAPY, 2022; 29 (8-9)

Alpha-synuclein (alpha-syn), encoded by the SNCA gene, is a major participant in the pathophysiology of Parkinson's disease (PD). Its functions have b......

JIF:4.883

SIX3 function in cancer: progression and comprehensive analysis

期刊: CANCER GENE THERAPY, 2022; 29 (11)

The homeobox gene family encodes transcription factors that are essential for cell growth, proliferation, and differentiation, and its dysfunction is ......

JIF:4.883

Pathophysiological role of ion channels and transporters in HER2-positive breast cancer

期刊: CANCER GENE THERAPY, 2022; 29 (8-9)

The incidence of breast cancer (BC) has been increasing each year, and BC is now the most common malignant tumor in women. Among the numerous BC subty......

JIF:4.883

Dicer deletion in hepatocytes promotes macrophages M1 polarization through dysregulated miR-192-3p/IGF2 in non-alcoholic steatohepatitis and hepatocellular carcinoma

期刊: CANCER GENE THERAPY, 2022; 29 (8-9)

Macrophages plays a vital role in the development of non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), but the polarization of ......

JIF:4.883

Alternative splicing events in tumor immune infiltration in renal clear cell carcinomas

期刊: CANCER GENE THERAPY, 2022; 29 (10)

Alternative splicing (AS) is a gene regulatory mechanism that drives protein diversity and dysregulation of AS plays a significant role in tumorigenes......

JIF:4.883

Human umbilical cord blood mesenchymal stem cells-derived exosomal microRNA-503-3p inhibits progression of human endometrial cancer cells through downregulating MEST

期刊: CANCER GENE THERAPY, 2022; 29 (8-9)

Endometrial cancer (EC) is a group of epithelial malignant tumors that occur in the endometrium. The specific pathogenesis is not revealed, hence, the......

JIF:4.883

SHMT2 promotes cell viability and inhibits ROS-dependent, mitochondrial-mediated apoptosis via the intrinsic signaling pathway in bladder cancer cells

期刊: CANCER GENE THERAPY, 2022; 29 (10)

Mitochondrial serine hydroxymethyltransferase (SHMT2) catalyzes the conversion of serine to glycine and concomitantly produces one-carbon units to sup......

JIF:4.883

Somatic copy number alteration predicts clinical benefit of lung adenocarcinoma patients treated with cytokine-induced killer plus chemotherapy

期刊: CANCER GENE THERAPY, 2022; 29 (8-9)

Somatic copy number alterations (SCNA), which are widespread in cancer, can predict the efficacy of immune checkpoint inhibitors in non-small-cell lun......

JIF:4.883

RDIVpSGP motif of ASPP2 binds to 14-3-3 and enhances ASPP2/k18/14-3-3 ternary complex formulation to promote BRAF/MEK/ERK signal inhibited cell proliferation in hepatocellular carcinoma

期刊: CANCER GENE THERAPY, 2022; 29 (11)

The Apoptosis Stimulating Protein of p53 2 (ASPP2) is a heterozygous insufficient tumor suppressor; however, its molecular mechanism(s) in tumor suppr......

JIF:4.883

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