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Human Cytomegalovirus-IE2 Affects Embryonic Liver Development and Survival in Transgenic Mouse

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 14 (2)

BACKGROUND & AIMS: Congenital human cytomegalovirus (HCMV) infection is a common cause of liver injury. The major immediate-early protein 2 (IE2) ......

DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid Metabolism and Suppresses Diet-Induced Hepatic Steatosis

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 14 (6)

BACKGROUND & AIMS: Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver-related morbidity and mortality whereas the pathogenic mecha......

Liver Regeneration in Chronic Liver Injuries: Basic and Clinical Applications Focusing on Macrophages and Natural Killer Cells

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 14 (5)

BACKGROUND & AIMS: Liver regeneration is a necessary but complex process involving multiple cell types besides hepatocytes. Mechanisms underlying ......

The miR-23b/27b/24-1 Cluster Inhibits Hepatic Fibrosis by Inactivating Hepatic Stellate Cells

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 13 (5)

BACKGROUND & AIMS: Hepatic fibrosis is characterized by hepatic stellate cell (HSC) activation and transdifferentiation-mediated extracellular mat......

Hepatocyte-Secreted Autotaxin Exacerbates Nonalcoholic Fatty Liver Disease Through Autocrine Inhibition of the PPAR alpha/FGF21 Axis

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 14 (5)

BACKGROUND & AIMS: The prevalence of nonalcoholic fatty liver disease (NAFLD) has reached epidemic proportions globally as a result of the rapid i......

Hepatic Leptin Signaling Improves Hyperglycemia by Stimulating MAPK Phosphatase-3 Protein Degradation via STAT3

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 14 (5)

BACKGROUND & AIMS: Obesity-related hyperglycemia, with hepatic insulin resistance, has become an epidemic disease. Central neural leptin signaling......

Hepatic Reduction in Cholesterol 25-Hydroxylase Aggravates Diet-induced Steatosis

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 13 (4)

BACKGROUND & AIMS: Cholesterol 25-hydroxylase (Ch25h), converting cholesterol to 25-hydroxycholesterol (25-HC), is critical in modulating cellular......

TM9SF4 Is a Crucial Regulator of Inflammation and ER Stress in Inflammatory Bowel Disease

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 14 (2)

BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is a major intestinal disease. Excessive inflammation and increased endoplasmic reticulum (ER)......

Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 13 (5)

BACKGROUND & AIMS: Cancer stemness and immune evasion are closely associated and play critical roles in tumor development and resistance to immuno......

Notch-Regulated c-Kit-Positive Liver Sinusoidal Endothelial Cells Contribute to Liver Zonation and Regeneration

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 13 (6)

c-Kit-positive liver sinusoidal endothelial cells promote hepatocyte proliferation and attenuate toxin-induced liver injuries. Notch mutation reshapes......

Aryl Hydrocarbon Receptor Deficiency in Intestinal Epithelial Cells Aggravates Alcohol-Related Liver Disease

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 13 (1)

BACKGROUND & AIMS: The ligand-activated transcription factor, aryl hydrocarbon receptor (AHR) can sense xenobiotics, dietary, microbial, and metab......

Single-cell Transcriptomic Architecture Unraveling the Complexity of Tumor Heterogeneity in Distal Cholangiocarcinoma

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 13 (5)

BACKGROUND & AIMS: Distal cholangiocarcinoma (dCCA) are a group of epithelial cell malignancies that occurs at the distal common bile duct, and ac......

Neutrophil-Epithelial Crosstalk During Intestinal Inflammation

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 14 (6)

Neutrophils are the most abundant leukocyte population in the human circulatory system and are rapidly recruited to sites of inflammation. Neutrophils......

PHLDB2 Mediates Cetuximab Resistance via Interacting With EGFR in Latent Metastasis of Colorectal Cancer

期刊: CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 2022; 13 (4)

BACKGROUND & AIMS: Latent metastasis of colorectal cancer (CRC) frequently develops months or years after primary surgery, followed by adjuvant th......

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