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MicroRNA-26a-3p rescues depression-like behaviors in male rats via preventing hippocampal neuronal anomalies

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (16)

Depression is a neuropsychiatric disease associated with neuronal anomalies within specific brain regions. In the present study, we screened microRNA ......

Tobacco smoking induces metabolic reprogramming of renal cell carcinoma

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (1)

BACKGROUND. Clear cell renal cell carcinoma (ccRCC) is the most common histologically defined renal cancer. However, it is not a uniform disease and i......

Neddylation stabilizes Na(v)1.1 to maintain interneuron excitability and prevent seizures in murine epilepsy models

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (8)

The excitability of interneurons requires Na(v)1.1, the alpha subunit of the voltage-gated sodium channel. Na(v)1.1 deficiency and mutations reduce in......

Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (10)

Genome-wide association studies (GWAS) for kidney function identified hundreds of risk regions; however, the causal variants, target genes, cell types......

Distinct projections from the infralimbic cortex exert opposing effects in modulating anxiety and fear

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (14)

Acknowledgments This work was supported by grants from the National Natural Science Foundation of China (82090032 and 31830033, to TMG; 31801007 and 8......

Mitigating oxygen stress enhances aged mouse hematopoietic stem cell numbers and function

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (1)

Bone marrow (BM) hematopoietic stem cells (HSCs) become dysfunctional during aging (i.e., they are increased in number but have an overall reduction i......

Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (4)

The relationship between adiposity and metabolic health is well established. However, very little is known about the fat depot, known as paracardial f......

DACH1 protects podocytes from experimental diabetic injury and modulates PTIP-H3K4Me3 activity

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (10)

Dachshund homolog 1 (DACH1), a key cell-fate determinant, regulates transcription by DNA sequence-specific binding. We identified diminished Dach1 exp......

Computerized tumor multinucleation index (MuNI) is prognostic in p16*oropharyngeal carcinoma

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (8)

BACKGROUND. Patients with p16+ oropharyngeal squamous cell carcinoma (OPSCC) are potentially cured with definitive treatment. However, there are curre......

Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (9)

Intestinal farnesoid X receptor (FXR) signaling is involved in the development of obesity, fatty liver disease, and type 2 diabetes. However, the role......

Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (10)

One of the primary mechanisms of tumor cell immune evasion is the loss of antigenicity, which arises due to lack of immunogenic tumor antigens as well......

IL-36 in chronic inflammation and fibrosis - bridging the gap?

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (2)

IL-36 is a member of the IL-1 superfamily and consists of three agonists and one receptor antagonist (IL-36Ra). The three endogenous agonists, IL-36 a......

TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (8)

Immune checkpoint blockade therapy has demonstrated promising clinical outcomes for multiple cancer types. However, the emergence of resistance as wel......

SUMOylation promotes extracellular vesicle-mediated transmission of lncRNA ELNAT1 and lymph node metastasis in bladder cancer

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (8)

Small ubiquitin-like modifier (SUMO) binding (termed SUMOylation) emerged as the inducer for the sorting of bioactive molecules into extracellular ves......

Tissue-resident PSGL1(lo)CD4(+) T cells promote B cell differentiation and chronic graft-versus-host disease associated autoimmunity

期刊: JOURNAL OF CLINICAL INVESTIGATION, 2021; 131 (1)

CD4(+) T cell interactions with B cells play a critical role in the pathogenesis of systemic autoimmune diseases such as systemic lupus and chronic gr......

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